SARS-CoV-2引发缺血性脑卒中的机制研究进展

Research Progress on the Mechanisms of SARS-CoV-2 Inducing Ischemic Stroke

新型冠状病毒(Severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)目前仍在全球肆虐传播,在引发2019新冠肺炎(Corona virus disease 2019,COVID-19)的同时,还能造成感染者中枢神经系统的损伤。缺血性脑卒中是COVID-19相关神经系统损伤常见病之一。本文归纳出SARS-CoV-2进入中枢的途径,以及该病毒是如何通过介导氧化应激反应、肾素-血管紧张素系统的失调、攻击血管内皮细胞、激活NLRP3炎症小体、释放中性粒细胞胞外陷阱、引发细胞因子风暴等一系列分子机制导致缺血性脑卒中的发病,以期为疾病的临床预防和治疗提供一些新的见解和思路。

Severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2) continues to spread worldwide.Not only does it cause coronavirus disease 2019(COVID-19), it can also damage the central nervous system.Ischemic stroke is one of the most common diseases of nervous system associated with COVID-19. This paper introduces the route of SARS-CoV-2 entering the central nervous system, as well as how the virus is mediated by oxidative stress reaction, disorders of the renin – angiotensin system, attacks vascular endothelial cells, activates the NLRP3 inflammasome, releases neutrophil extracellular traps, triggers a cytokine storm and a series of molecular mechanisms lead to the onset of ischemic stroke. This paper will provide some new ideas for clinical prevention and treatment of the diseases.