肾衰宁颗粒联合“神阙穴”隔物灸对脾肾气虚兼湿浊证血透患者临床疗效探讨

Clinical Effect of Shenshuining Granule Combined with"Shenque Point"Moxibustion in the Treatment of Hemodialysis Patients with Spleenkidney Qi Deficiency and Dampness Turbidity Syndrome

目的探讨肾衰宁颗粒联合“神阙穴”隔物灸对脾肾气虚兼湿浊证血透患者临床疗效。方法随机选取2020年1—12月福建中医药大学附属宁德中医院收治的脾肾气虚兼湿浊证血透患者60例,采用随机对照的方式分为对照组以及研究组,每组30例。对照组接受肾衰宁颗粒治疗,研究组接受肾衰宁颗粒联合“神阙穴”隔物灸治疗,对比两组患者的疗效。结果治疗前,两组患者的钙、磷、PTH对比,差异无统计学意义(P>0.05);治疗后,研究组钙(2.68±0.23)mmol/L高于对照组(2.12±0.45)mmol/L,磷(1.41±0.23)mmol/L、PTH(172.93±12.44)ng/L低于对照组(1.89±0.23)mmol/L、(235.52±34.12)ng/L,差异有统计学意义(t=6.069、8.082、9.439,P<0.05)。治疗前,两组患者的BUN、Scr、GFR对比,差异无统计学意义(P>0.05);治疗后,研究组BUN(10.39±1.44)mmol/L、Scr(231.94±45.33)mmol/L、GFR(16.39±1.45)mL/min低于对照组(14.49±3.44)mmol/L、(318.58±37.23)mmol/L、(25.32±3.41)mL/min,差异有统计学意义(t=6.021、8.089、13.199,P<0.05)。研究组的治疗有效率(96.67%)高于对照组(73.33%),差异有统计学意义(χ^(2)=4.705,P<0.05)。结论肾衰宁颗粒联合“神阙穴”隔物灸治疗脾肾气虚兼湿浊证血透患者,其临床疗效显效,能够有效地改善患者的各项实验室指标。

Objective To investigate the clinical effect of Shenshuining granule combined with"Shenque point"moxibustion on the hemodialysis patients with spleen-kidney qi deficiency and damp turbidity syndrome.Methods From January to December 2020,60 hemodialysis patients with spleen and kidney Qi deficiency and wet turbidity syndrome admitted to Ningde Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine were randomly selected and divided into control group and study group by random control method,with 30cases in each group.The control group was treated with Shenshuanning granules,while the study group was treated with Shenshuanning granules combined with"Shenque point"septum moxibustion.The efficacy of the two groups was compared.Results Before treatment,there was no statistically significant difference in calcium,phosphorus and PTH between the two groups(P>0.05).After treatment,calcium in the study group(2.68±0.23)mmol/L was higher than that in the control group(2.12±0.45)mmol/L.Phosphorus(1.41±0.23)mmol/L and PTH(172.93±12.44)ng/L were lower than those of control group(1.89±0.23)mmol/L and(235.52±34.12)ng/L,and the differences were statistically significant(t=6.069,8.082,9.439,P<0.05).Before treatment,there was no statistically significant difference in BUN,Scr and GFR between the two groups(P>0.05).After treatment,BUN(10.39±1.44)mmol/L,Scr(231.94±45.33)mmol/L,GFR(16.39±1.45)mL/min in the study group were lower than those in the control group(14.49±3.44)mmol/L,(318.58±37.23)mmol/L,(25.32±3.41)mL/min,and the difference was statistically significant(t=6.021,8.089,13.199,P<0.05).The effective rate of the study group(96.67%)was higher than that of the control group(73.33%),and the difference was statistically significant(χ^(2)=4.705,P<0.05).Conclusion Shenshuining granules combined with"Shenque point"moxibustion with partitions in the treatment of hemodialysis patients with spleen-kidney qi deficiency and damp turbidity syndrome has a marked clinical effect and can effectively improve various laboratory indicators of patients.