丹鳖胶囊、少腹逐瘀颗粒联合地屈孕酮治疗超声下子宫内膜回声不均的内膜息肉的临床效果

Clinical Effect of Danbie Capsules, Shaofu Zhuyu Granules Combined with Dydrogesterone on Endometrial Polyp with Endometrium Echo Inhomogeneous under Ultrasound

目的:研究丹鳖胶囊、少腹逐瘀颗粒联合地屈孕酮治疗超声下子宫内膜回声不均的内膜息肉的临床效果。方法:选取2021年2月-2022年2月郑州大学第三附属医院妇科门诊收治的90例子宫内膜息肉患者(B超声像表现为子宫内膜回声不均),按照实际治疗方案将其分为对照组、观察组1和观察组2,每组30例。对照组在月经第14天给予地屈孕酮片治疗10 d,观察组1在月经第10天给予丹鳖胶囊、少腹逐瘀颗粒、地屈孕酮片治疗14 d,观察组2在月经第14天给予丹鳖胶囊、少腹逐瘀颗粒、地屈孕酮片治疗10 d。比较三组雌二醇(E2)、促黄体生成素(LH)、卵泡刺激素(FSH)、血红蛋白(Hb)水平、月经及B超情况、疗效及不良反应发生情况。结果:治疗后,三组血清E2、LH、FSH均高于治疗前,差异均有统计学意义(P<0.05)。治疗后,观察组1和观察组2的Hb均高于治疗前,差异均有统计学意义(P<0.05)。治疗后,观察组1和观察组2的血清LH、FSH均高于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组2的血清E2与对照组比较,差异有统计学意义(P<0.05)。治疗后,三组Hb、月经经期天数、子宫内膜回声不均率、子宫内膜稍高回声率比较,差异均无统计学意义(P>0.05)。治疗后,三组子宫内膜厚度比较,差异有统计学意义(P<0.05)。另外,观察组1和观察组2的总有效率均高于对照组,差异均有统计学意义(P<0.05)。观察组1和观察组2的总有效率比较,差异无统计学意义(P>0.05)。三组均无不良反应发生。结论:丹鳖胶囊、少腹逐瘀颗粒联合地屈孕酮治疗超声子宫内膜回声不均的内膜息肉的效果较好,无不良反应发生,值得临床借鉴。

Objective: To study the clinical effect of Danbie Capsules, Shaofu Zhuyu Granules combined with Dydrogesterone on endometrial polyp with endometrium echo inhomogeneous under ultrasound. Method: A total of 90 patients with endometrial polyps(endometrium echo inhomogeneous under ultrasound) admitted to the Department of Gynecology of the Third Affiliated Hospital of Zhengzhou University from February 2021 to February 2022 were selected, they were divided into control group, observation group 1 and observation group 2 according to the actual treatment plan, with 30 cases in each group. The control group was treated with Dydrogesterone Tablets on the 14th day of menstruation for 10 d;the observation group 1 was treated with Danbie Capsules, Shaofu Zhuyu Granules and Dydrogesterone Tablets on the 10th day of menstruation for 14 d;the observation group 2 was treated with Danbie Capsules, Shaofu Zhuyu Granules and Dydrogesterone Tablets on the 14th day of menstruation for 10 d. The levels of estradiol(E2), luteinizing hormone(LH), follicle stimulating hormone(FSH), hemoglobin(Hb), menstruation and B-ultrasound, efficacy and occurrence of adverse reactions were compared among the three groups. Result: After treatment, serum E2, LH and FSH in three groups were higher than those before treatment,the differences were statistically significant(P<0.05). After treatment, Hb levels in the observation group 1 and observation group 2 were higher than those before treatment, the differences were statistically significant(P<0.05).After treatment, serum LH and FSH in the observation group 1 and observation group 2 were higher than those in the control group, the differences were statistically significant(P<0.05). After treatment, the serum E2 in the observation group 2 was significantly different from that in the control group(P<0.05). After treatment, there were no significant differences in Hb, menstrual period days, endometrial echo heterogeneity and endometrial hyperecho among the three groups(P>0.05). After treatment, there was significant difference in endometrial thickness among the three groups(P<0.05). In addition, the total effective rate in the observation group 1 and observation group 2 was higher than that in the control group, the differences were statistically significant(P<0.05). There was no significant difference in the total effective rate between the observation group 1 and observation group 2(P>0.05). No adverse reactions occurred in the three groups. Conclusion: The combination of Danbie Capsules and Shaofu Zhuyu Granules and Didrogesterone in the treatment of endometrial polyps with with endometrium echo inhomogeneous under ultrasound is effective, and there is no adverse reaction, which is worthy of clinical reference.