结直肠癌伴腹膜转移治疗的研究进展

Advances in treatment of peritoneal metastasis from colorectal cancer

结直肠癌是全球第三大常见癌症,也是与癌症相关死亡的第四大常见原因。转移性疾病仍然是结直肠癌死亡的主要原因,除了淋巴和血源传播途径外,结直肠癌还会引起肿瘤细胞的腹腔传播,最终导致腹膜癌。随着各种治疗的进展,转移性结直肠癌患者的预后明显改善,但对伴有腹膜转移的患者疗效并不理想。最近越来越多的研究表明,肿瘤细胞减灭术(CRS)和腹腔热灌注化疗(HIPEC)可使结直肠癌伴腹膜转移患者受益,预后较好,腹腔内加压气溶胶化疗(PIPAC)、新辅助化疗、Radspherin短距离辐射等新型疗法也相继出现。本文就结直肠癌伴腹膜转移的治疗研究进展作一综述。

Colorectal cancer is the third most common cancer in the world and the fourth most common cause of cancer-related death.Metastatic diseases are still the main cause of colorectal cancer death.Except lymphatic and blood transmission routes,colorectal cancer will also cause the intraperitoneal transmission of tumor cells and eventually lead to peritoneal cancer.With the progress of various treatments,the prognosis of patients with metastatic colorectal cancer has improved significantly,but the curative effect on patients with peritoneal metastasis is not ideal.Recently,more and more evidence shows that patients with colorectal cancer with peritoneal metastasis can benefit from cytoreductive surgery(CRS)and hot intraperitoneal chemotherapy(HIPEC),and have a good prognosis.New therapies such as pressurized intraperitoneal aerosol chemotherapy(PIPAC),neoadjuvant chemotherapy,and Radspherin short distance radiation also appear.This article reviews the research progress of colorectal cancer with peritoneal metastasis.