基于质谱分析的新精神活性物质代谢研究进展

Advances in Metabolism of New Psychoactive Substances Based on Mass Spectrometry

近年来,新精神活性物质愈发泛滥,滋生了违法犯罪等社会问题,严重危害公众健康和社会安定。新精神活性物质在人体内代谢迅速,通过质谱方法检测其特征代谢物能够有效确定摄入情况。该文通过检索、整理和讨论相关文献,综述了近5年新精神活性物质体外、体内的代谢研究,总结了不同方法的适用性和优缺点,并与真实人体样本数据进行了比较。最后展望了代谢研究方法的发展趋势,以期为鉴定代谢产物,推断代谢途径与生物标志物等新精神活性物质代谢研究提供参考。

New psychoactive substances(NPSs) have been proliferating in recent years, posing a threat to public health and social stability through contributing to social issues like crime.NPSs are quickly metabolized in the human body,while mass spectrometry could be used to effectively determine a substance’s ingestion by detecting its distinctive metabolites.The in vitro and in vivo metabolic studies of NPSs in the last five years are reviewed in this paper by searching,organizing,and discussing the pertinent literature.The applicability,benefits and drawbacks of various methods are also summarized and compared to data from real human samples.Finally,the development trend of metabolic research methods is looked ahead with a view to providing references for metabolic studies of NPSs such as metabolite identification and metabolite inference.