保胎灵片辅助西药治疗习惯性流产疗效观察及对血清生殖激素水平的影响

Curative Observation of Baotailing Pills Assisting Western Medicine for Habitual Abortion and Its Effect on Reproductive Hormone Levels in Serum

目的:观察保胎灵片辅助西药治疗习惯性流产的临床疗效及其对血清生殖激素水平的影响。方法:选取162例习惯性流产患者,按照随机数字表法分为对照组与治疗组各81例。对照组采取常规西药(地屈孕酮片+那屈肝素钙注射液+黄体酮注射液)治疗,治疗组在对照组的基础上加用保胎灵片治疗。比较2组治疗前后血清生殖激素水平[雌二醇(E_(2))、人绒毛膜促性腺激素β (β-HCG)、孕酮(P)]和免疫指标[干扰素-γ (IFN-γ)、白细胞介素-4 (IL-4)],以及妊娠成功率、临床疗效和不良反应情况。结果:治疗组总有效率为98.77%,对照组为91.36%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组血清E_(2)、β-HCG、P水平比较,差异无统计学意义(P>0.05);治疗后,2组上述各项生殖激素水平均较治疗前升高(P<0.05),且治疗组各项指标均高于对照组(P<0.05)。治疗前,2组血清IFN-γ、IL-4比较,差异无统计学意义(P>0.05)。治疗后,2组IFN-γ水平均较治疗前降低(P<0.05),IL-4水平均较治疗前升高(P<0.05);且治疗组IFN-γ水平低于对照组(P<0.05),IL-4水平高于对照组(P<0.05)。治疗后随访4个月,治疗组妊娠成功率为97.53%,对照组87.65%,2组比较,差异有统计学意义(P<0.05)。治疗期间,治疗组不良反应发生率为4.94%,对照组为8.64%,2组比较,差异无统计学意义(P>0.05)。结论:保胎灵片辅助西药治疗习惯性流产疗效显著,能有效改善患者免疫功能和体内生殖激素水平,提高妊娠率,且不良反应相对较少。

Objective:To observe the clinical effect of Baotailing Pills combined with western medicine for habitual abortion and its effect on reproductive hormone levels in serum.Methods:A total of 162 cases of patients with habitual abortion were selected and divided into the control group and the treatment group according to the random number table method,with 81 cases in each group.The control group was treated with routine western medicine,including dydrogestrone Tablets,Nadroparin Calcium Injection and Progesterone Injection,and the treatment group was additionally treated with Baotailing Pills based on the treatment of the control group.The levels of serum reproductive hormones including estradiol(E_(2)),human chorionic gonadotropin β(β-HCG) and progesterone(P),immune indexes including interferon-γ(IFN-γand Interleukin-4(IL-4) before and after treatment,as well as the successful rat of pregnancy,the clinica effects and adverse reactions were compared between the two groups.Results:The total effective rate was 98.77%in the treatment group and 91.36%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of E_(2),β-hCG and P in serum between the two groups(P>0.05);after treatment,the levels of the above serum reproductive hormones in the two groups were increased when compared with those before treatment(P<0.05),and each index in the treatment group was higher than that in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of IFN-γ and IL-4 between the two groups(P>0.05).After treatment,the levels of IFN-γ in the two groups were decreased(P<0.05),and IL-4 levels were increased(P<0.05);IFN-γ level in the treatment group was lower than that in the control group(P<0.05),and IL-4 level was higher(P<0.05).During the four-month follow-up after treatment,the successful rate of pregnancy was 97.53%in the treatment group and87.65%in the control group,differences being significant(P<0.05).During treatment,the incidence of adverse reactions was 4.94%in the treatment group and 8.64%in the control group,there being no significance in the difference(P>0.05).Conclusion:Baotailing Pills assisting western medicine for habitual abortion have a significant curative effect,which can effectively improve the immune function of patients,levels of reproductive hormones in the body,and the pregnancy rate,with relatively few adverse reactions.