肿瘤细胞减灭术后应用不同药物腹腔热灌注化疗治疗晚期卵巢癌的效果研究

Effect of intraperitoneal hyperthermic chemotherapy with different drugs on advanced ovarian cancer after cytoreductive surgery

目的探讨肿瘤细胞减灭术后应用不同药物腹腔热灌注化疗治疗晚期卵巢癌的效果。方法抽取2019年5月至2022年4月于南阳市中心医院行肿瘤细胞减灭术的晚期卵巢癌患者78例,按照术后治疗方案分为对照组和研究组,每组39例。对照组术后给予5-氟尿嘧啶腹腔热灌注化疗联合静脉化疗,研究组术后给予5-氟尿嘧啶、卡铂腹腔热灌注化疗联合静脉化疗。比较两组近期治疗效果、腹水治疗效果、术后腹胀持续时间、肛门排气时间、化疗不良反应情况。结果研究组近期总治疗有效率为94.87%(37/39),高于对照组的74.36%(29/39),P<0.05。研究组腹水治疗总有效率(97.44%,38/39)与对照组(89.74%,35/39)比较,差异未见统计学意义(P>0.05)。两组术后腹胀持续时间、肛门排气时间比较差异未见统计学意义(P>0.05)。研究组骨髓抑制、肝功能损伤、胃肠道反应发生率为12.82%(5/39)、20.51%(8/39)、30.77%(12/39),低于对照组的38.46%(15/39)、64.10%(25/39)、66.67%(26/39),P均<0.05。结论与5-氟尿嘧啶联合静脉化疗比较,5-氟尿嘧啶、卡铂腹腔热灌注化疗联合静脉化疗应用于晚期卵巢癌肿瘤细胞减灭术后,近期治疗效果明显,能减少骨髓抑制、肝功能损伤等化疗不良反应。

Objective To investigate the effects of intraperitoneal hyperthermic chemotherapy with different drugs on advanced ovarian cancer after cytoreductive surgery.Methods A total of 78 patients with advanced ovarian cancer who underwent cytoreductive surgery in Nanyang Central Hospital from May 2019 to April 2022 were selected,and the patients were divided into control group and study group according to the postoperative treatment plans,with 39 cases in each group.The control group was given 5-fluorouracil intraperitoneal hyperthermic perfusion chemotherapy combined with intravenous chemotherapy,and the study group was given 5-fluorouracil and carboplatin intraperitoneal hyperthermic perfusion chemotherapy combined with intravenous chemotherapy.The short-term treatment effect,treatment effect on ascites,postoperative abdominal distension duration,anal exhaust time,and adverse reactions of chemotherapy were compared between the two groups.Results The short-term total effective rate of the study group was 94.87%(37/39),which was higher than 74.36%(29/39)of the control group(P<0.05).There was no significant difference in the total effective rate of ascites treatment between the study group(97.44%,38/39)and the control group(89.74%,35/39),P>0.05.There was no significant difference in postoperative abdominal distension duration and anal exhaust time between the two groups(P>0.05).The incidence of bone marrow suppression,liver function damage and gastrointestinal reactions in the study group were 12.82%(5/39),20.51%(8/39),and 30.77%(12/39),respectively,which were lower than 38.46%(15/39),64.10%(25/39)and 66.67%(26/39)in the control group(all P<0.05).Conclusions Compared with 5-fluorouracil intraperitoneal hyperthermic perfusion chemotherapy combined with intravenous chemotherapy,5-fluorouracil and carboplatin intraperitoneal hyperthermic perfusion chemotherapy combined with intravenous chemotherapy has significant short-term therapeutic effects on advanced ovarian cancer after cytoreduction,which can reduce the adverse reactions of chemotherapy such as bone marrow suppression and liver function damage.