血清hs-CRP、sICAM-1水平与急性心肌梗死患者PCI治疗预后的相关性

Correlation of serum levels of hs-CRP and sICAM-1 with prognosis of PCI in patients with acute myocardial infarction

目的观察血清超敏C反应蛋白(hs-CRP)、可溶性细胞间黏附分子-1(sICAM-1)水平与急性心肌梗死(AMI)患者经皮冠状动脉介入(PCI)治疗预后的相关性。方法抽取2019年11月至2021年2月信阳市第四人民医院收治的AMI患者98例,均行PCI治疗并接受1年随访,均于入院时检测血清hs-CRP、sICAM-1水平。按照随访期间不良心血管事件发生情况评估预后,并据此分为预后不良组、预后良好组。比较两组基线资料及血清hs-CRP、sICAM-1水平,分析血清hs-CRP、sICAM-1水平与AMI患者PCI治疗预后的关系。结果98例AMI患者PCI治疗后随访1年,其中预后不良20例,预后良好78例。预后不良组入院时血清hs-CRP、sICAM-1水平高于预后良好组(t=8.56、8.57,P均<0.05),两组其他基线资料比较差异未见统计学意义(P>0.05)。点二列相关性检验结果显示,血清hs-CRP、sICAM-1水平与AMI患者PCI治疗预后成正相关(r=0.659、0.658,P均<0.05)。Logistic回归分析结果显示,入院时血清hs-CRP、sICAM-1高表达是AMI患者PCI治疗预后不良的风险因子(OR>1,P<0.05)。结论血清hs-CRP、sICAM-1水平与AMI患者PCI治疗预后存在一定关系,且血清hs-CRP、sICAM-1高表达提示AMI患者PCI治疗预后不良发生率较高。

Objective To observe the correlation of levles of serum high-sensitivity C-reactive protein(hs-CRP)and soluble intercellular adhesion molecule-1(sICAM-1)with the prognosis of percutaneous coronary intervention(PCI)for acute myocardial infarction(AMI).Methods A total of 98 AMI patients admitted to Xinyang Fourth People’s Hospital from November 2019 to February 2021 were selected,all of them received PCI,and were followed up for 1 year,and their serum hs-CRP and sICAM-1 levels were detected at admission.The prognosis was evaluated according to the occurrence of adverse cardiovascular events during the follow-up period,and they were divided into a poor prognosis group and a good prognosis group accordingly.The baseline data and serum hs-CRP and sICAM-1 levels of the two groups were compared,and the relationship of serum levels of hs-CRP and sICAM-1 with the prognosis of patients with AMI after PCI was analyzed.Results Ninety-eight patients with AMI were followed up for 1 year after PCI.Among them,20 cases had poor prognosis and 78 cases had good prognosis.The serum hs-CRP and sICAM-1 levels in the poor prognosis group were higher than those in the good prognosis group(t=8.56,8.57;all P<0.05),and there was no significant difference in other baseline data between the two groups(P>0.05).The results of point-two-column correlation test showed that serum hs-CRP and sICAM-1 levels were positively correlated with the prognosis of AMI patients after PCI(r=0.659,0.658;all P<0.05).The results of Logistic regression analysis showed that the high expression of serum hs-CRP and sICAM-1 at admission were risk factors for poor prognosis in patients with AMI after PCI(OR>1,P<0.05).Conclusions There is a certain relationship between the levels of serum hs-CRP and sICAM-1 and the prognosis of AMI patients after PCI,and the high expression of serum hs-CRP and sICAM-1 indicate that the incidence of poor prognosis in AMI patients after PCI is higher.