二甲双胍治疗妊娠糖尿病的效果研究

Study on the Effect of Metformin in the Treatment of Gestational Diabetes Mellitus

目的研究二甲双胍治疗妊娠糖尿病的效果。方法选取福州市长乐区妇幼保健院2021年8月—2022年8月收治的妊娠糖尿病患者60例,按照随机数表法分为对照组(30例)和观察组(30例),对照组患者采用胰岛素治疗,观察组患者联用二甲双胍治疗,对比两组患者在不同治疗方法下的临床治疗效果、血糖水平、不良妊娠结局、产妇并发症情况、新生儿并发症情况、不良反应情况。结果观察组患者临床治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组妊娠糖尿病患者治疗后空腹血糖、餐后2h血糖、糖化血红蛋白水平低于对照组,差异有统计学意义(P<0.05)。结论联用二甲双胍与胰岛素治疗妊娠糖尿病的效果显著优于单用胰岛素治疗,并且患者在联用二甲双胍治疗后临床治疗效果显著好转,血糖水平显著下降,不良妊娠结局、产妇并发症情况、新生儿并发症情况、不良反应情况显著减少。

Objective To study the effect of metformin in the treatment of gestational diabetes mellitus.Methods Sixty patients with gestational diabetes mellitus admitted to Fuzhou Changle District Maternal and Child Health Hospital from August 2021 to August 2022 were selected.They were divided into control group(30 cases)and observation group(30 cases)according to the random number table method.The patients in the control group were treated with insulin and the patients in the observation group were treated with metformin in combination.The clinical treatment effect,blood glucose level,adverse pregnancy outcome,maternal complications,neonatal complications and adverse reactions of patients in the two groups were compared under different treatment methods.Results The total clinical treatment efficiency of patients in the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin in the observation group of patients were lower than those in the control group after treatment,and the difference was statistically significant(P<0.05).Conclusion The effect of combining metformin and insulin in the treatment of gestational diabetes mellitus is significantly better than that of insulin treatment alone.Patients had significantly better clinical outcomes and significantly lower blood glucose levels,and significantly fewer adverse pregnancy outcomes,maternal complication conditions,neonatal complication conditions,and adverse events after combination metformin therapy.