分析门冬胰岛素在妊娠糖尿病治疗中的应用效果

Analysis of Insulin Aspart in the Treatment of Gestational Diabetes

目的分析门冬胰岛素在妊娠期糖尿病患者临床治疗中的可行性。方法选取2020年12月—2021年12月莆田涵江医院收治的130例妊娠期糖尿病患者,根据患者的治疗方法分为两组,每组65例。观察组患者接受门冬胰岛素治疗,对照组患者接受人工合成胰岛素治疗。比较两组患者血糖、妊娠结局、不良事件及不良反应发生率。结果治疗后,观察组空腹血糖、餐后2h血糖、糖化血红蛋白均显著低于对照组,差异有统计学意义(P<0.05)。观察组血糖达标率显著高于对照组,差异有统计学意义(χ^(2)=16.955,P<0.05)。观察组不良妊娠结局发生率显著低于对照组,差异有统计学意义(χ^(2)=4.432,P=0.035)。观察组新生儿不良事件发生率低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论在妊娠糖尿病患者临床治疗阶段,与传统用药方案相比,门冬胰岛素的治疗效果更好,可以显著降低患者的血糖水平,避免不良妊娠结局发生,具有可行性。

Objective To analyze the feasibility of insulin aspart in clinical treatment of gestational diabetes.Methods 130 patients with gestational diabetes who were admitted to Putian Hanjiang Hospital from December 2020 to December 2021 were selected and divided into two groups according to the treatment methods,65 patients in each group.Patients in the observation group received aspartic insulin treatment,while patients in the control group received synthetic insulin treatment.The rationality of the treatment plan was evaluated according to the blood glucose,pregnancy outcome,adverse event and adverse reactions were compared between the two groups.Results The fasting glucose,2 h postprandial glucose and glycosylated hemoglobin of the patients in the observation group were significantly lower than those in the control group after treatment,and the difference was statistically significant(P<0.05).The glucose compliance rates of the observation group was significantly higher than the control group,the difference was statistically significant(χ^(2)=16.955,P<0.05).The incidence of adverse pregnancy outcomes in the observation group was significantly lower than in the control group,and the difference was statistically significant(χ^(2)=4.432,P=0.035).The incidence of neonatal adverse events in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion In the clinical treatment stage of patients with gestational diabetes,compared with the traditional medication,insulin aspart has a better therapeutic effect,can significantly reduce the blood sugar level of patients,and avoid adverse pregnancy outcomes,which is feasible.