高剂量维生素D联合门冬胰岛素治疗妊娠期糖尿病对其血糖代谢与妊娠结局的影响

Effect of High-dose Vitamin D Combined with Menthol Insulin on Glucose Metabolism and Pregnancy Outcome in Gestational Diabetes Mellitus

目的分析妊娠期糖尿病患者应用高剂量维生素D联合门冬胰岛素治疗的临床效果,探究对患者血糖代谢与妊娠结局的影响。方法选取2021年6月—2022年6月福建省妇幼保健院收治的60例妊娠期糖尿病患者为研究对象,按随机抽签方式分组,其中参照组(30例)应用常规剂量维生素D联合门冬胰岛素治疗,研究组(30例)应用高剂量维生素D联合门冬胰岛素治疗,分析并对比两组患者血糖代谢水平、妊娠结局、胰岛素敏感性。结果治疗后,研究组患者糖化血红蛋白、空腹血糖水平均明显低于参照组,差异有统计学意义(t=2.644、5.620,P<0.05);研究组患者不良妊娠结局发生率(6.66%)明显低于参照组,差异有统计学意义(χ^(2)=6.666,P=0.009);治疗后,研究组患者空腹胰岛素、胰岛素抵抗指数均低于参照组,胰岛素分泌指数高于参照组,差异有统计学意义(t=7.279、2.407、4.468,P<0.05)。结论应用高剂量维生素D联合门冬胰岛素治疗方式,能够改善患者胰岛素敏感性和血脂代谢水平,降低患者不良妊娠结局的发生率,临床治疗效果确切。

Objective To analyze the clinical effects of high-dose vitamin D combined with menthol insulin treatment in patients with gestational diabetes mellitus and to investigate the effects on patients’glucose metabolism and pregnancy outcomes.Methods 60 cases patients with gestational diabetes mellitus admitted to the Fujian Provincial Maternal and Child Health Hospital from June 2021 to June 2022 were selected as the research objects.The patients were grouped by random drawing,in which the reference group(30 cases)applied conventional dose vitamin D combined with menthol insulin treatment,the study group(30 cases)was treated with high-dose vitamin D combined with menadione insulin.The glucose metabolism level,pregnancy outcome,and insulin sensitivity of patients in both groups were analyzed and compared.Results After treatment,the glycosylated hemoglobin and fasting blood glucose of the study group were significantly lower than those of the reference group,and the differences were statistically significant(t=2.644,5.620,P<0.05).The incidence of adverse pregnancy outcomes in the study group(6.66%)was significantly lower than that in the reference group,and the differences were statistically significant(χ^(2)=6.666,P=0.009).The fasting insulin and insulin resistance index of the study group were lower than those of the reference group,and the insulin secretion index was higher than that of the reference group,the difference was statistically significant(t=7.279,2.407,4.468,P<0.05).Conclusion The application of high-dose vitamin D combined with menadione insulin therapy can improve insulin sensitivity and lipid metabolism levels and reduce the incidence of adverse pregnancy outcomes in patients.The clinical treatment effect is definite and worthy of wide recommendation in clinical practice.