分析玻璃体注射手术针对不同类型糖尿病视网膜病变的临床疗效

Analysis of Clinical Efficacy of Vitreous Injection Surgery for Different Types of Diabetic Retinopathy

目的分析对不同类型糖尿病视网膜病变患者实施玻璃体注射手术治疗的疗效和价值。方法回顾性选取2020年1月—2022年2月张掖市石学良眼科医院收治的40例重度非增殖性糖尿病视网膜病变合并黄斑水肿患者作为组1,同时选取40例增殖性糖尿病视网膜病变患者作为组2。两组均给予玻璃体腔注射阿柏西普治疗。对比两组最佳矫正视力、黄斑中心视网膜厚度、氧化应激以及术后不良反应发生率。结果与组1相比,组2患者治疗后最佳矫正视力较高、黄斑中心视网膜厚度较低、氧化应激水平改善较显著,差异有统计学意义(P<0.05);两组患者术后不良反应发生率对比,差异无统计学意义(P>0.05)。结论不论是重度非增殖性糖尿病视网膜病变合并黄斑水肿,还是增殖性糖尿病视网膜病变患者,给予玻璃体腔注射阿柏西普治疗均具有显著效果,但对增殖性糖尿病视网膜病变患者来说,治疗后黄斑中心视网膜厚度明显较低。

Objective To analyze the efficacy and value of vitreous injection surgery in patients with different types of diabetic retinopathy.Methods 40 patients with severe non-proliferative diabetic retinopathy combined with macular edema admitted to Zhangye Shixueliang Eye Hospital from January 2020 to February 2022 were retrospectively se-lected as group 1,40 patients with proliferative diabetic retinopathy were selected as group 2.All patients were treated with vitreous cavity injection of abciximab.The best corrected visual acuity,central macular retinal thickness,oxidative stress,and the incidence of postoperative adverse effects were compared between the two groups.Results Compared with group 1,the best corrected visual acuity was higher,the macular central retinal thickness was lower,and the level of oxidative stress improved significantly after treatment in group 2,the difference was statistically sig-nificant(P<0.05);there was no statisticallysignificant difference in the incidence of postoperative adverse effects be-tween the two groups(P>0.05).Conclusion Whether patients with severe non-proliferative diabetic retinopathy com-bined with macular edema or proliferative diabetic retinopathy were treated with vitreous cavity injection of abciximab,the treatment had significant effects.However,in patients with proliferative diabetic retinopathy,the macular central retinal thickness was significantly lower after treatment.