糖尿病肾病终末期患者采用腹膜透析与血液透析的临床对照研究

A Controlled Clinical Study on the Use of Peritoneal Dialysis Versus Hemodialysis in Patients with End-stage Diabetic Nephropathy

目的分析糖尿病肾病终末期患者采用腹膜透析与血液透析治疗的临床效果。方法以2020年1月—2022年2月期间在龙岩市第二医院接受治疗的糖尿病肾病终末期患者60例为研究对象,按随机数表法进行分组,每组30例。观察组患者接受腹膜透析治疗,对照组患者接受血液透析治疗。对比两组治疗后血清溶质下降率、治疗前后炎症介质指标改善情况、肾功能改善情况。结果治疗后两组P、PTH较治疗前下降,且观察组下降比对照组更明显,差异有统计学意义(P<0.05)。治疗后观察组炎症介质指标低于对照组,差异有统计学意义(P<0.05)。两组患者的每日尿量水平对比,观察组更高,差异有统计学意义(P<0.05)。结论糖尿病肾病终末期患者接受腹膜透析治疗可纠正钙磷代谢,改善炎症介质指标以及保护残余肾功能。

Objective To analyze the efficacy of peritoneal dialysis and hemodialysis in diabetic patients with endstage nephropathy.Methods 60 patients with end-stage diabetic nephropathy treated in Longyan Second Hospital between January 2020 and February 2022 were taken as the study subjects,and they were grouped by virtue of the random number table method,there were 30 cases in each group.Patients in the observation group were treated with peritoneal dialysis and patients in the control group were treated with hemodialysis.The reduction rate of serum solute,the improvement of inflammatory mediators before and after treatment,and the improvement of renal function before and after treatment were compared between the two groups.Results After treatment,the P and PTH in two groups de-creased compared with those before treatment,and the decrease in observation group was more obvious than the control group,the difference was statistically significant.After treatment,the index of inflammatory mediators in the observa-tion group was lower than those in the control group,the difference was statistically significant(P<0.05).The daily urine output levels of the patients in both groups were higher for the observation group,the difference was statistically significant(P<0.05).Conclusion Patients with end-stage diabetic nephropathy treated with peritoneal dialysis can correct calcium and phosphorus metabolism,improve inflammatory mediator indexes and protect residual renal function.