α-硫辛酸联合甲钴胺治疗在2型糖尿病周围神经病变患者中的应用效果分析

Analysis of the Effect ofα-lipoic Acid Combined with Methylcobalamin Therapy in Patients with Type 2 Diabetic Peripheral Neuropathy

目的观察α-硫辛酸联合甲钴胺治疗2型糖尿病周围神经病变的临床效果。方法选择2020年1月—2021年12月福建省大田县总医院收治的2型糖尿病周围神经病变患者122例,随机分为研究组、对照组。对照组常规治疗,研究组联合用药治疗。比较两组治疗后血糖水平、氧化应激及炎性因子指标、TCSS评分、神经传导功能、生活质量评分、治疗效果、不良反应发生率。结果研究组治疗效果95.08%高于对照组的85.24%,研究组不良反应率6.55%低于对照组的14.76%,差异有统计学意义(χ^(2)=7.450、7.520,P<0.05)。研究组治疗后空腹血糖、餐后2h血糖与糖化血红蛋白值、HIF-1α、VEGF较对照组低,差异有统计学意义(t=11.018、12.642、10.215、11.647、10.218,P<0.05)。研究组氧化应激显著高于对照组,炎性因子水平低于对照组,差异有统计学意义(P<0.05)。研究组TCSS评分较对照组显著下降,神经传导功能、生活质量评分显著高于对照组,差异有统计学意义(P<0.05)。结论α-硫辛酸联合甲钴胺治疗2型糖尿病周围神经病变效果确切。

Objective To observe the clinical effect ofα-lipoic acid combined with methylcobalamin in the treatment of type 2 diabetic peripheral neuropathy.Methods From January 2020 to December 2021,122 patients with type 2 diabetic peripheral neuropathy were admitted to Datian County General Hospital,Fujian Province,and random Ly divided into study group and control group.The control group was treated conventionally and the study group was treated with combined medication.Compare the blood glucose level,oxidative stress and inflammatory factor index,TCSS score,nerve conduction function,quality of life score,treatment effect and adverse reaction rate between the two groups after treatment.Results The treatment effect of the study group(95.08%)was higher than that of the control group(85.24%).The adverse reaction rate in the study group was 6.55%lower than 14.76%in the control group,and the difference was statistically significant(χ^(2)=7.450,7.520,P<0.05).The fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin,HIF-1αand VEGF in the study group were lower than those in the control group,and the difference was statistically significant(t=11.018,12.642,10.215,11.647,10.218,P<0.05).The oxidative stress in the study group was significantly higher than that in the control group.The level of inflammatory factors was lower than that of the control group,and the difference was statistically significant(P<0.05).The TCSS score of the study group was significantly lower than that of the control group.The TCSS score of the study group decreased signifi-cantly compared with the control group,and the nerve conduction function and quality of life score were significantly higher than the control group,and the difference was statistically significant(P<0.05).Conclusionα-Lipoic acid combined with methylcobalamin is effective in the treatment of type 2 diabetic peripheral neuropathy.