miRNA-30c-5p与急性冠脉综合征PCI术后发生对比剂肾病的相关性

Correlation of miRNA-30c-5p with the Development of Contrast Nephropathy after PCI for Acute Coronary Syndrome

目的分析miRNA-30c-5p与急性冠脉综合征(acute coronary syndrome,ACS)经皮冠状动脉介入术(percutaneous coronary intervention,PCI)后发生对比剂肾病(contrast-induced nephropathy,CIN)的相关性。方法选择2020年10月—2021年12月济南市第八人民医院心内科、CCU及ICU住院的急性冠脉综合征并行PCI患者553例。根据PCI术后对比剂肾病发生情况将患者分为非CIN组(499例)和CIN组(54例)。比较两组患者miRNA-30c-5p表达差异。采用Pearson相关分析miRNA-30c-5p与sCr、eGFR的关系。绘制ROC曲线评价miRNA-30c-5p对PCI术后CIN的预测价值。结果术前两组患者miRNA-30c-5p血清表达水平差异无统计学意义(t=0.171,P=0.864)。术后非CIN组患者miRNA-30c-5p血清表达水平(1.15±0.46)pg/mL明显低于CIN组患者(3.19±0.71)pg/mL,差异有统计学意义(t=29.084,P<0.01)。miRNA-30c-5p与sCr呈正相关(r=0.657,P<0.01),与eGFR呈负相关(r=-0.812,P<0.01)。miRNA-30c-5p预测ACS患者行PCI术后发生CIN的ROC曲线下面积为0.883。结论miRNA-30c-5p与急性冠脉综合征PCI术后发生CIN具有相关性,可以预测CIN的发生。

Objective To analyze the correlation between miRNA-30c-5p and the occurrence of contrast nephropathy(CIN)after percutaneous coronary intervention(PCI)for acute coronary syndrome(ACS).Methods 553 patients with acute coronary syndrome with parallel PCI admitted to the Department of Cardiology,CCU and ICU of the Jinan Eighth People’s Hospital from October 2020 to December 2021 were selected.According to the occurrence of contrast nephropathy after PCI,the patients were divided into the non-CIN group(499 cases)and the CIN group(54 cases).The miRNA-30c-5p expression differences between the two groups were compared.Pearson correlation was used to analyze the relationship between miRNA-30c-5p and sCr and eGFR.ROC curves were plotted to evaluate the predictive value of miRNA-30c-5p on CIN after PCI.Results There was no statistically difference in the preoperative miRNA-30c-5p serum expression level between the two groups(t=0.171,P=0.864).Postoperatively,the serum expression level of miRNA-30c-5p in the non-CIN group(1.15±0.46)pg/mL was significantly lower than the CIN group(3.19±0.71)pg/mL,the difference was statistically significant(t=29.084,P<0.01).miRNA-30c-5p was positively correlated with sCr(r=0.657,P<0.01)and with eGFR negative correlation(r=-0.812,P<0.01).The ROC area under the curve of the miRNA-30c-5p for predicting CIN development in ACS patients undergoing PCI was 0.883.Conclusion miRNA-30c-5p is correlated with the occurrence of CIN after PCI in acute coronary syndrome and can predict the occurrence of CIN.