PAF-1、PCT、Lp-PLA2血清水平变化与AIS患者NIHSS评分的相关性及临床意义

Correlation and Clinical Significance of Changes in Serum Levels of PAF-1,PCT and Lp-PLA2 with NIHSS Score in AIS Patients

目的探讨急性缺血性脑卒中(acute ischemic stroke,AIS)患者血清血小板膜糖蛋白-血小板活化因子-1(PAF-1)、降钙素原(PCT)、脂蛋白磷脂酶A2(Lp-PLA2)水平与美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分的相关性。方法回顾性选取2021年9月—2022年3月徐州医科大学附属医院收治的AIS患者110例并将其作为观察组,按照患者NIHSS评分和脑梗死面积将其分为轻度60例、中度27例、重度23例,根据患者出入院的NIHSS评分下降百分比分为预后良好组84例、预后不良组26例,另选取同期于本院进行体检的健康人群65名作为对照组。比较各组血清PAF-1、PCT、Lp-PLA2水平和NIHSS评分及其相关性。结果与对照组相比,观察组血清PAF-1、PCT、Lp-PLA2水平较高,差异有统计学意义(P<0.05);与预后良好相比,预后较差AIS患者血清PAF-1、PCT、Lp-PLA2水平较高,差异有统计学意义(P<0.05);轻度、中度、重度AIS患者血清PAF-1、PCT、Lp-PLA2水平呈逐渐升高趋势,且重度患者各指标水平均高于轻度、中度,差异有统计学意义(P<0.05);血清PAF-1、PCT、Lp-PLA2水平与NIHSS评分呈正相关关系,差异有统计学意义(r=0.435、0.415、0.461,P<0.05)。结论血清PAF-1、PCT、Lp-PLA2水平与NIHSS评分呈正相关关系,临床上可通过检测上述指标水平变化评估疾病的严重程度并对患者预后情况进行评价,进而为临床上治疗AIS提供一定参考。

Objective To investigate the correlation between serum platelet membrane glycoprotein-platelet activating factor-1(PAF-1),PCT and lipoprotein phospholipase A2(Lp-PLA2)levels and National Institutes of Health Stroke Scale(NIHSS)scores in patients with acute ischemic stroke(AIS).Methods From September 2021 to March 2022,110 patients with AIS admitted to the Affiliated Hospital of Xuzhou Medical University were retrospectively selected as the observation group.According to NIHSS score and cerebral infarction area,patients were divided into mild 60cases,moderate 27 cases,severe 23 cases.The patients were divided into good prognosis group(n=84)and poor prognosis group(n=26)according to the percentage decrease of NIHSS score.Another 65 healthy people were selected as the control group.The serum levels of PAF-1,PCT,lp-PLA2 and NIHSS score were compared between the two groups.Results Compared with the control group,the serum levels of PAF-1,PCT and Lp-PLA2 in the observation group were higher,the difference was statistically significant(P<0.05).Serum PAF-1,PCT,lp-PLA2 levels in patients with poor prognosis of AIS were higher than those in patients with good prognosis,the difference was statistically significant(P<0.05).The serum levels of PAF-1,PCT and Lp-PLA2 in mild,moderate and severe AIS patients were gradually increased,and the levels of all indexes in severe patients were higher than those in mild and moderate patients,the difference was statistically significant(P<0.05).Serum PAF-1,PCT and Lp-PLA2 levels were positively correlated with NIHSS score(r=0.435,0.415,0.461,P<0.05).Conclusion Serum PAF-1,PCT and Lp-PLA2 levels are positively correlated with NIHSS score.Clinically,the severity of the disease can be assessed by detecting the changes in the levels of the above indicators and evaluating the prognosis of patients,so as to provide a reference for the clinical treatment of AIS.