结核感染T细胞检测用于肺结核诊断的临床价值研究

Clinical Value Study of T-cell Test for Tuberculosis Diagnosis

目的探讨临床诊断肺结核疾病采用结核感染T细胞检测技术的效果及应用价值。方法选取2021年2—12月宜兴市人民医院接诊的疑似肺结核病住院患者150例为研究对象,分别进行结核抗体检验(胶体金法)与结核感染T细胞检测(磁微粒化学发光法),以临床综合诊断结果为金标准,记录汇总两种检测方法结果,对比两种检测方法灵敏度、特异度及准确度。结果150例疑似肺结核住院患者经临床综合诊断结果显示,45例患者确诊为肺结核,占比30.00%,105例患者结果为阴性,占比70.00%。结核感染T细胞检测灵敏度(97.78%)、特异度(98.10%)及准确度(98.00%)均高于结核抗体检验,差异有统计学意义(χ^(2)=14.254、81.306、90.447,P<0.05)。结论临床鉴别诊断肺结核疾病可采取结核感染T细胞检测技术,具有较高的准确率,能够为临床提供可靠数据支持。

Objective To investigate the effect and application value of using tuberculosis infection T-cell assay technology for clinical diagnosis of pulmonary tuberculosis disease.Methods 150 patients with suspected pulmonary tuberculosis admitted to Yixing People’s Hospital from February to December 2021 was selected as the study objectes.Tuberculosis antibody test(colloidal gold method)and T-cell test for tuberculosis infection(magnetic particle chemiluminescence method)were performed respectively.The results of the two assays were recorded and summarized according to the clinical synthesis diagnostic results as the gold standard.The sensitivity,specificity and accuracy of the two assays were compared.Results 150 patients hospitalized with suspected tuberculosis showed that 45 patients were diagnosed with tuberculosis disease(30.00%)and 105 patients had negative results(70.00%).The sensitivity(97.78%),specificity(98.10%)and accuracy(98.00%)of the TB infection T-cell test were higher than the TB antibody test,the difference was statistically significant(χ^(2)=14.254,81.306,90.447,P<0.05).Conclusion Clinical differential diagnosis of pulmonary tuberculosis disease can be made by the T-cell test for tuberculosis infection,which has a high accuracy rate and can provide reliable data for clinical support.