氟哌噻吨美利曲辛片联合阿普唑仑治疗非糜烂性胃食管反流病伴焦虑的疗效

Efficacy of Haloperidol Melitrexin Tablets Combined with Alprazolam in the Treatment of Non-erosive Gastroesophageal Reflux Disease with Anxiety

目的观察氟哌噻吨美利曲辛片(flupentixide melitracine tablets,FM)与阿普唑仑联合在非糜烂性胃食管反流病(non-erosive reflux disease,NERD)伴焦虑患者临床治疗中的疗效。方法选取甘肃省兰州市第一人民医院于2019年1月—2021年2月收治的80例NERD伴焦虑患者,并以随机数表法分为对照组(n=40)与联合组(n=40)。对照组仅采用阿普唑仑予以治疗,而联合组基于对照组疗法联合FM予以治疗,评价两组的临床疗效和安全性。结果联合组总有效率(92.50%)比对照组(75.00%)更高,差异有统计学意义(χ^(2)=4.501,P<0.05)。两组治疗后的烧心、反酸及胸痛的典型症状评分以及焦虑和睡眠质量评分均低于治疗前,且联合组与对照组相比更低,差异有统计学意义(P<0.05)。联合组不良反应发生率与对照组相比更低,差异有统计学意义(P<0.05)。结论在对NERD伴焦虑患者展开治疗时,FM联合阿普唑仑具有更明显的效果,可有效改善患者不适症状、焦虑状态和睡眠质量,且安全性更高,值得应用和推广。

Objective To observe the efficacy of combining haloperidol melitrexin tablets(FM)with alprazolam in the clinical treatment of patients with non-erosive gastroesophageal reflux disease(NERD)with anxiety.Methods 80 patients with NERD with anxiety admitted to the Lanzhou First People’s Hospital of Gansu Province from January 2019and February 2021 were selected and randomly divided into a control group(n=40)and a combination group(n=40)with random number table method.Among them,the control group was treated with alprazolam only,while the combination group was treated with FM based on the control therapy,and the clinical efficacy and safety of the two groups were evaluated.Results The total effective rate in the combination group(92.50%)was higher compared with the control group(75.00%),the difference was statistically significant(χ^(2)=4.501,P<0.05).The typical symptom scores of heartburn,acid reflux and chest pain,as well as anxiety and sleep quality scores in both groups after treatment were lower than those before treatment,and score of the combination group were lower compared with the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the combination group was lower compared with the control group,the difference was statistically significant(P<0.05).Conclusion In the treatment of patients with NERD with anxiety,FM combined with alprazolam has more obvious effects,can effectively improve the discomfort,anxiety state and quality of sleep with higher safety,which is worthy of application and promotion.