瑞芬太尼复合丙泊酚靶控输注在妇科腹腔镜手术中的应用效果及安全性分析

Application effect and safety analysis of remifentanil combined with propofol target-controlled infusion in gynecological laparoscopic surgery

目的 探讨瑞芬太尼复合丙泊酚靶控输注在妇科腹腔镜手术中的应用效果及安全性。方法 选取于本院行妇科腹腔镜手术的患者80例为研究对象,按照随机数字表法分为对照组及研究组,每组40例。对照组采用瑞芬太尼和七氟醚静吸复合麻醉,研究组采用瑞芬太尼复合丙泊酚靶控麻醉。记录两组的麻醉起效时间、麻醉苏醒时间、拔管时间,比较不同时间点心率(HR)及平均动脉压(MAP)水平,观察不良反应发生情况。结果 研究组麻醉起效、麻醉苏醒及拔管时间均短于对照组,差异显著(P<0.05)。麻醉诱导前,两组HR及MAP水平比较,差异无统计学意义(P>0.05);插管后,两组HR及MAP水平均高于麻醉诱导前,但研究组各指标水平均低于对照组,差异显著(P<0.05);手术结束时,研究组HR及MAP水平恢复至麻醉诱导前,且各指标水平均低于对照组,差异显著(P<0.05)。研究组不良反应总发生率为5.00%,低于对照组的20.00%,差异显著(P<0.05)。结论 将瑞芬太尼复合丙泊酚靶控输注用于妇科腹腔镜手术中可缩短麻醉起效时间、术后苏醒时间及拔管时间,还可维持血流动力学稳定,降低不良反应发生率,值得临床推广使用。

Objective To investigate the efficacy and safety of target-controlled infusion of remifentanil combined with propofol in gynecological laparoscopic surgery.Methods A total of 80 patients who underwent gynecological laparoscopic surgery in our hospital were selected as the research objects.They were divided into a control group and a study group according to random number table method,with 40 cases in each group.Remifentanil and sevoflurane combined anesthesia were used in the control group,while target-controlled infusion ofremifentanil combined with propofol was used in the study group.The onset time of anesthesia,recovery time of anesthesia and extubation time of the two groups were recorded;the heart rate(HR)and mean arterial pressure(MAP)levels at different time points were compared;the occurrence of adverse reactions was observed.Results The time of anesthesia onset,anesthesia recovery and extubation in the study group were shorter than those in the control group,Significant difference(P<0.05).Before anesthesia induction,there were no significant differences in HR and MAP levels between the two groups(P>0.05);after intubation,the levels of HR and MAP in both groups were higher than before anesthesia induction,but the levels of indicators in the study group were lower than those in the control group,Significant difference(P<0.05);at the end of the operation,the level of HR and MAP in the study group returned to the level before anesthesia induction,and all indexes were lower than those in the control group,Significant difference(P<0.05).The total incidence of adverse reactions in the study group was 5.00%,lower than 20.00%in the control group,Significant difference(P<0.05).Conclusion Target-controlled infusion of remifentanil combined with propofol in gynecological laparoscopic surgery can shorten the onset time of anesthesia,postoperative recovery time and extubation time,maintain hemodynamic stability,reduce the incidence of adverse reactions,and is worthy of clinical promotion.