米非司酮联合中药治疗胎盘粘连的临床效果

Clinical effect of mifepristone combined with traditional Chinese medicine in the treatment of placental adhesions

目的研究米非司酮联合中药治疗胎盘粘连的效果。方法选取本院收治的80例胎盘粘连患者为研究对象,采用随机数字表法分为对照组及研究组,每组40例。对照组采用米非司酮治疗,研究组采用米非司酮联合中药治疗。比较两组治疗效果。结果研究组子宫复旧评分高于对照组,宫腔内异常回声发生率低于对照组,差异有统计学意义(P<0.05)。治疗前,两组卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E_(2))水平比较,差异无统计学意义(P>0.05);治疗后,两组FSH、LH、E_(2)水平均改善,且研究组FSH、LH、E_(2)水平均高于对照组,差异有统计学意义(P<0.05)。治疗前,两组白细胞介素-6(IL-6)、肿瘤坏死因子-a(TNF-α)、C反应蛋白(CRP)水平比较,差异无统计学意义(P>0.05);治疗后,两组IL-6、TNF-α、CRP水平均升高,但研究组IL-6、TNF-α、CRP水平均低于对照组,差异有统计学意义(P<0.05)。研究组治疗总有效率为95.00%,高于对照组的75.00%,差异有统计学意义(P<0.05)。结论米非司酮联合中药治疗胎盘粘连的效果理想,可促进子宫复旧,改善卵巢功能,降低炎症反应,值得临床推广使用。

Objective To study the effect of mifepristone combined with Chinese medicine on placental adhesion.Methods 80 patients with placental adhesion admitted to our hospital were selected as the research objects,and were divided into a control group and a study group by random number table method,with 40 cases in each group.The control group was treated with mifepristone,and the study group was treated with mifepristone combined with Chinese medicine.The therapeutic effects of the two groups were compared.Results The uterine remodeling score of the study group was higher than that of the control group,and the incidence of uterine abnormal echo was lower than that of the control group,the difFerences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of follicle stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E_(2))between the two groups(P>0.05);after treatment,the levels of FSH,LH and E_(2)in both groups were improved,and the levels of FSH,LH and E_(2)in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of interleukin-6(IL-6),tumor necrosis factor-a(TNF-α)and C-reactive protein(CRP)between the two groups(P>0.05);after treatment,the levels of IL-6,TNF-αand CRP were increased in both groups,but the levels of IL-6,TNF-αand CRP in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of the study group was 95.00%,higher than 75.00%of the control group,and the difference was statistically significant(P<0.05).Conclusion Mifepristone combined with traditional Chinese medicine has an ideal effect in the treatment of placental adhesion,which can promote uterine involution,improve ovarian function and reduce inflammation.