丙泊酚与咪达唑仑用于老年机械通气患者中镇静效果的研究

Study on the Sedative Effect of Propofol and Midazolam in Elderly Mechanically Ventilated Patients

目的:探讨丙泊酚与咪达唑仑用于老年机械通气患者中的镇静效果。方法:选取我院2019年8月至2020年10月重症监护病室(ICU)行机械通气的老年患者60例为研究对象,将其随机分为对照组(30例,咪达唑仑)和观察组(30例,丙泊酚)。观察两组患者给药前、后血流动力学和呼吸频率的变化;比较两组患者镇静满意时间、停药后苏醒时间以及苏醒后认知功能MMSE评分。结果:给药前、两组患者的平均动脉压、心率和呼吸频率比较无明显差异(P>0.05);给药后,两组患者平均动脉压、心率和呼吸频率均明显下降,且丙泊酚组低于咪达唑仑组,差异具有统计学意义(P<0.05);丙泊酚组镇静满意时间、用药后唤醒时间均显著短于咪达唑仑组,差异具有统计学意义(P<0.05);苏醒后1 d丙泊酚组MMSE评分明显高于咪达唑仑组,差异有统计学意义(P<0.05)。结论:应用丙泊酚对老年机械通气患者进行镇静治疗,较咪达唑仑能够获得更好的镇静效果。

Objective: To investigate the sedative effect of propofol and midazolam in elderly patients with mechanical ventilation. Methods: A total of 60 elderly patients who received mechanical ventilation in the intensive care unit(ICU) of our hospital from August 2019 to October 2020 were selected as the research objects,and they were randomly divided into the control group(30 cases, midazolam) and the observation group. group(30 cases, propofol). The changes of hemodynamics and respiratory rate before and after administration in the two groups were observed;the sedation satisfaction time, recovery time after drug withdrawal and MMSE score of cognitive function after recovery were compared between the two groups. Results: Before administration, there was no significant difference in mean arterial pressure, heart rate and respiratory rate between the two groups(P > 0.05). The phenol group was lower than the midazolam group, and the difference was statistically significant(P<0.05). <0.05);the MMSE score of the propofol group was significantly higher than that of the midazolam group 1 day after recovery,and the difference was statistically significant(P<0.05). Conclusion: The application of propofol for sedation in elderly mechanically ventilated patients can achieve better sedative effect than midazolam.