哌拉西林钠他唑巴坦钠联合左氧氟沙星对支气管扩张患者气道功能、炎症反应的影响

Effect of Piperacillin Sodium and Tazobactam Sodium Combined with Levofloxacin on Airway Function and Inflammatory Response in Patients with Bronchiectasis

目的分析哌拉西林钠他唑巴坦钠(PS/TS)联合左氧氟沙星对支气管扩张患者气道功能、炎症反应的影响。方法选取吉水县人民医院于2019年3月-2021年6月收治的66例支气管扩张病例,按照随机数字表法分为对照组(33例)与观察组(33例)。对照组应用PS/TS治疗,观察组给予PS/TS联合左氧氟沙星治疗,比较两组气道功能[呼气峰值流速(PEF)、1 s用力呼气容积(FEV_(1))、用力肺活量比值(FEV_(1)/FVC)]、血气分析指标[血氧饱和度(SaO_(2))、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]、血清炎性因子[白细胞(WBC)、白介素6(IL-6)、C反应蛋白(CRP)]、症状改善情况[24 h痰液量、改良版英国医学研究委员会呼吸问卷(mMRC)评分、莱塞斯特咳嗽生命质量问卷(LCQ)评分]。结果两组PEF、FEV_(1)、FEV_(1)/FVC均有升高,且观察组高于对照组(P<0.05);两组PaO_(2)、SaO_(2)升高,PaCO_(2)下降,且观察组PaO_(2)、SaO_(2)高于对照组,PaCO_(2)低于对照组(P<0.05);两组WBC、IL-6、CRP水平均有下降,且观察组较对照组低(P<0.05);两组24 h痰液量及mMRC、LCQ评分均有下降,且观察组低于对照组(P<0.05)。结论PS/TS与左氧氟沙星联合治疗支气管扩张,可有效改善患者气道功能,提升血氧状态,下调炎症表达,促进症状改善。

Objective To analyze the effects of piperacillin sodium and tazobactam sodium(PS/TS)combined with levofloxacin on airway function and inflammatory response in patients with bronchiectasis.Methods A total of 66 cases of bronchiectasis admitted to Jishui County People's Hospital from March 2019 to June 2021 were selected and divided into control group(33 cases)and observation group(33 cases)according to the random number table method.The control group was treated with PS/TS,and the observation group was treated with PS/TS combined with levofloxacin.The airway function[peak expiratory flow(PEF),forced expiratory volume in one second(FEV_(1)),forced expiratory volume in one second/forced vital capacity(FEV_(1)/FVC)],blood gas analysis indexes[saturation of blood oxygen(SaO_(2)),arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2))],serum inflammatory factors[white blood cell(WBC),interleukin 6(IL-6),C-reactive protein(CRP)],symptom improvement[24 h sputum volume,modified British Medical Research Council Respiratory Questionnaire(mMRC)score,Leicester Cough Quality of Life Questionnaire(LCQ)score]were compared between the two groups.Results PEF,FEV_(1)and FEV_(1)/FVC in the two groups increased,and those in the observation group were higher than those in the control group(P<0.05).PaO_(2)and SaO_(2)in the two groups increased,PaCO_(2)decreased,and PaO_(2)and SaO_(2)in the observation group were higher than those in the control group,PaCO_(2)was lower than that in the control group(P<0.05).The levels of WBC,IL-6 and CRP in the two groups decreased,and those in the observation group were lower than those in the control group(P<0.05).The 24 h sputum volume,mMRC and LCQ scores of the two groups decreased,and those of the observation group were lower than those in the control group(P<0.05).Conclusion PS/TS combined with levofloxacin in the treatment of bronchiectasis can effectively improve airway function,improve blood oxygen status,down-regulate inflammatory expression and promote symptom improvement.