莫西沙星对慢性支气管炎急性发作期患者细菌清除率的影响

Effect of Moxifloxacin on Bacterial Clearance Rate in Patients with Acute Exacerbation of Chronic Bronchitis

目的探究莫西沙星对慢性支气管炎急性发作期(AECB)患者细菌清除率的影响。方法选取2019年5月-2021年8月吉水县人民医院收治的72例AECB患者,经随机数字表法分为对照组36例,给予左氧氟沙星治疗;观察组36例,给予莫西沙星治疗。比较两组临床疗效、症状缓解时间(发热、咯痰、咳痰、气喘)、细菌清除率、血气指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、血氧饱和度(SaO_(2))]、药物不良反应。结果观察组临床有效率高于对照组(P<0.05);观察组症状缓解时间(发热、咳嗽、咳痰、气喘)短于对照组(P<0.05);观察组细菌总清除率高于对照组(P<0.05);两组治疗后PaO_(2)、SaO_(2)升高,PaCO_(2)下降,且观察组PaO_(2)、SaO_(2)高于对照组,PaCO_(2)低于对照组(P<0.05);观察组药物不良反应发生率低于对照组(P<0.05)。结论莫西沙星治疗AECB疗效确切,其细菌清除率高,可加快症状缓解,改善血气指标水平,且药物不良反应少。

Objective To investigate the effect of moxifloxacin on bacterial clearance rate in patients with acute exacerbation of chronic bronchitis(AECB).Methods A total of 72 patients with AECB admitted to Jishui County People's Hospital from May 2019 to August 2021 were selected and divided into control group(36 cases,received levofloxacin treatment)and treatment group(36 cases,received moxifloxacin treatment)by random number table method.The clinical efficacy,symptom relief time(fever,expectoration,expectoration,asthma),bacterial clearance rate,blood gas index[arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2)),saturation of blood oxygen(SaO_(2))]and adverse drug reactions were compared between the two groups.Results The clinical effective rate of the observation group was higher than that of the control group(P<0.05).The symptom relief time(fever,cough,sputum,asthma)in the observation group was shorter than that in the control group(P<0.05).The total bacterial clearance rate of the observation group was higher than that of the control group(P<0.05).After treatment,PaO_(2) and SaO_(2) increased and PaCO_(2) decreased in the two groups,and PaO_(2) and SaO_(2) in the observation group were higher than those in the control group,and PaCO_(2) was lower than that in the control group(P<0.05).The incidence of adverse drug reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Moxifloxacin is effective in the treatment of AECB,and its bacterial clearance rate is high,which can accelerate symptom relief,improve blood gas index levels,and have few adverse drug reactions.