炎症在糖尿病肾病中的致病性及其治疗的研究进展

Research Progress on the Pathogenicity of Inflammation in Diabetic Nephropathy and its Treatment

糖尿病肾病(DN)是慢性肾脏病(CKD)的主要原因,其发病率呈逐年上升趋势,增加了终末期肾病(ESRD)发生风险。近年来研究发现,炎症介质(细胞粘附分子、趋化因子和细胞因子)和细胞内信号通路的抗炎作用已在DN实验模型中突显成效,可减少蛋白尿和肾脏病变。此外,许多炎症分子已被证明可用于识别具有发生肾脏并发症高风险的糖尿病患者。本文主要对炎症反应与DN的关系以及免疫细胞、免疫炎症介质和细胞信号通路在DN中的作用作一综述,并总结炎症的新治疗策略,以期为DN的预防和治疗提供理论支撑。

Diabetic nephropathy(DN)is the main cause of chronic kidney disease(CKD),and its incidence is increasing year by year,which increases the risk of end-stage renal disease(ESRD).Recent studies have found that the anti-inflammatory effects of inflammatory mediators(cell adhesion molecules,chemokines and cytokines)and intracellular signaling pathways have been highlighted in DN experimental models,which can reduce proteinuria and renal lesions.In addition,many inflammatory molecules have been shown to be used to identify diabetic patients with a high risk of renal complications.This article mainly reviews the relationship between inflammatory response and DN and the role of immune cells,immune inflammatory mediators and cell signaling pathways in DN,and summarizes new treatment strategies for inflammation,in order to provide theoretical support for the prevention and treatment of DN.