垂体后叶素联合卡前列素氨丁三醇治疗胎盘早剥产后出血临床观察

Clinical Observation of Pituitrin Combined with Carboprost Tromethamine in the Treatment of Postpartum Hemorrhage After Placental Abruption

目的垂体后叶素联合卡前列素氨丁三醇治疗胎盘早剥产后出血的临床疗效。方法选取医院2019年3月至2022年3月收治的胎盘早剥产后出血患者68例,按随机数字表法分为对照组和观察组,各34例。对照组患者予卡前列素氨丁三醇,观察组患者加用垂体后叶素。结果观察组临床有效率为97.06%,显著高于对照组的82.35%(P<0.05);观察组患者产后15,30min及产后2,24h出血量显著少于对照组(P<0.05);观察组患者治疗后的纤维蛋白原、D-二聚体、血小板计数水平均显著高于对照组,活化部分凝血酶原时间显著长于对照组(P<0.05);观察组产后不良事件总发生率显著低于对照组(8.82%比32.35%)。结论垂体后叶素联合卡前列素氨丁三醇治疗胎盘早剥产后出血,能提高临床止血有效性,有效调节患者机体凝血功能。

Objective To observe the clinical efficacy of pituitrin combined with carboprost tromethamine in the treatment of postpartum hemorrhage after placental abruption.Methods A total of 68 patients with postpartum hemorrhage after placental abruption admitted in the hospital from March 2019 to March 2022 were randomly divided into the control group and the observation group,34 cases in each group.Patients in the control group were given carboprost tromethamine,on this basis,the patients in the observation group were given pituitrin.Results The clinical effective rate in the observation group was 97.06%,which was significantly higher than 82.35%(P<0.05).The amount of bleeding in the observation group at 15,30min and 2,24h postpartum was significantly less than that in the control group(P<0.05).The levels of fibrinogen,D-dimer and platelet count in the observation group after treatment were significantly higher than those in the control group,and the time of activating partial prothrombin was significantly longer than that in the control group(P<0.05).The total incidence of postpartum adverse events in the observation group was significantly lower than that in the control group.Conclusion Pituitrin combined with carboprost tromethamine in the treatment of postpartum hemorrhage after placental abruption can improve the effectiveness of clinical hemostasis and effectively regulate the coagulation function of patients.