运动锻炼调节miRNA对多种类型癌症的改善及机制的研究进展

Research Progress of the Regulation of miRNA by Exercise Improving Various Types of Cancer and the Mechanisms

目的:miRNA能作为抑癌因子调控癌细胞的有丝分裂期,阻断其增殖和扩散。运动锻炼通过调节miRNA的表达,明显降低癌症风险和减缓癌症进程,但其改善的癌症类型及其背后机制尚不明晰。方法:在中国知网、PubMed、Science Direct等数据库,以“exercise”“miRNA”“cancer”“mechanism”为关键词检索并分析相关文献,对运动锻炼调节miRNA改善的癌症类型及其相关机制进行综述。结果:运动锻炼能够调节血浆中运动敏感型miRNA的含量;运动锻炼诱导的miRNA可能对乳腺癌、前列腺癌、肝癌、胃癌、结直肠癌、肺癌有较好的改善作用;运动锻炼诱导的miRNA主要通过与促癌因子的3’-UTR结合,阻滞癌细胞有丝分裂前期和间期,从根源上切断癌细胞新蛋白质形成和DNA复制。结论:运动锻炼诱导的miRNA与促癌因子的3’-UTR结合阻断癌细胞进程,调节多种癌症类型;建议将运动锻炼作为辅疗手段用于癌症临床干预治疗。

Objective:miRNA can act as a tumor suppressor to regulate the mitotic phase of cancer cells and block their proliferation and migration.Exercise significantly reduce cancer risk and slow cancer progression by regulating miRNA expression.However,the types of cancer improved and the mechanism behind it are not fully understood.Methods:Through searching keywords“exercise”“miRNA”“cancer”“mechanism”in databases,such as CNKI,Pub Med,Science Direct,etc.,relevant literature was analyzed to summarize the types of cancer regulated by exercise regulating miRNA and their related mechanisms.Results:Exercise can increase the content of miRNA in plasma.miRNA induced by exercise may have better improvement effects on breast cancer,prostate cancer,liver cancer,stomach cancer,clorectal cancer and lung cancer.The exercise-induced miRNA block the prophase and interphase of mitosis in cancer cells by binding to the 3’-UTR of the oncogenic factor,thus cutting off the formation of new proteins and the replication of DNA in cancer cells.Conclusions:Exercise-induced miRNA bind to the 3’-UTR of the oncogenic factor to block the progression of cancer cells and regulate a variety of cancer types.It is suggested that exercise should be used as an auxiliary therapy in the clinical intervention treatment of cancer.