慢性冠状动脉综合征病人肝细胞生长因子的表达及其诊断价值

Expression and diagnostic value of hepatocyte growth factor in patients with chronic coronary syndrome

目的探讨慢性冠状动脉综合征(CCS)病人血清肝细胞生长因子(HGF)的变化及其诊断价值。方法选取2020年3~10月在我院心血管内科住院、临床诊断或者怀疑CCS并拟行冠脉造影的病人89例,根据冠脉造影检查结果,分为CCS组(56例)和非CHD组(33例)。收集所有病人的一般资料,检测并比较2组血脂、血糖、肾功能、BNP、LVEF、HGF水平。采用倾向性评分匹配(PSM)法控制混杂因素,二元Logistic回归分析CCS的影响因素,使用ROC曲线评估HGF对CCS的诊断效能。结果CCS组HGF血清水平显著高于非CHD组(P<0.05)。PSM前后二元Logistic回归分析显示:HGF(OR=1.004,95%CI:1.001~1.007,P<0.05)是CCS的危险因素。ROC曲线分析提示:HGF预测CCS的AUC为0.677(95%CI:0.567~0.788,P<0.05),敏感度为48.2%,特异度为87.9%。结论CCS病人血清的HGF水平显著高于非CHD者,其对CCS诊断有一定的价值,有助于早期识别CCS病人。

Objective To investigate the level of serum hepatocyte growth factoR(HGF)in the patients with chronic coronary syndrome(CCS)and its diagnostic value.Methods A total of 89 patients who were diagnosed oRsuspected as CCS and planned to undergo coronary angiography in ouRhospital from March to OctobeR2020 were selected,and they were divided into the CCS group(n=56)and the non-coronary heart disease(CHD)group(n=33)according to the results of coronary angiography.The general data of all patients were collected,and the levels of blood lipid,blood glucose,renal function,B-type natriuretic peptide(BNP),left ventriculaRejection fraction(LVEF)and HGF were detected and compared between two groups.Propensity score matching(PSM)method was used to control the confounding factors,and binary Logistic regression was used to analyze the influencing factors of CCS.ReceiveRoperating characteristic curve(ROC)was used to evaluate the diagnostic efficacy of HGF foRCCS.Results The serum level of HGF in the CCS group was significantly higheRthan that in non-CHD group(P<0.05).Binary Logistic regression analysis before and afteRPSM showed that HGF was the risk factoRfoRCCS(OR=1.004,95%CI:1.001-1.007,P<0.05).ROC curve analysis showed that the area undeRthe curve(AUC)of HGF predicting CCS was 0.677(95%CI:0.567-0.788,P<0.05),with a sensitivity of 48.2%and a specificity of 87.9%.Conclusions The level of serum HGF in the patients with CCS is significantly higheRthan that in the patients without CHD.The serum level of HGF shows predictive value foRCCS,which may be helpful in early identification of CCS.