摘要
早期再灌注是挽救缺血性心脏病的有效方式。但与之矛盾的是,缺血区域血运重建可能引起心肌缺血再灌注损伤(MIRI),导致更严重的心肌损伤。这不仅增加了患者的身体负担,甚至可能造成危及生命的严重后果。中药作为我国的传统药物,在MIRI预防和治疗中得到了广泛应用。随着对中药认识的逐渐深入,中药治疗MIRI的作用机制也被逐渐揭示,这不仅为中药治疗MIRI提供了理论保障,也为进一步阐明MIRI的发病机制提供了参考。基于此,本文对近年来中药治疗MIRI的研究进展进行了综述,期望对中药在MIRI预防治疗领域的应用提供参考。
Early reperfusion is an effective way to save ischemic myocardium.However,revascularization in ischemic area may cause the more serious myocardial ischemia-reperfusion injury(MIRI),which increases the burden of the body and may threaten the life of patients.Chinese medicine has been widely used in the prevention and treatment of MIRI.With accumulating knowledge on Chinese medicine,the mechanism of Chinese medicine against MIRI has been revealed,laying a theoretical basis for treating MIRI with Chinese medicine and further elucidating the pathogenesis of MIRI.On this basis,this article reviews Chinese medicine in the treatment of MIRI in recent years,which is expected to serve as a reference for the application of Chinese medicine in the prevention and treatment of MIRI.
作者
岳栋芳
李永芳
Yue Dongfang;Li Yongfang(Medical College of Qinghai University,Xining 810000)
出处
《中药药理与临床》
CAS
CSCD
北大核心
2022年第6期224-239,共16页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家自然科学基金项目(编号:81760761)。
关键词
中药
中药复方
心肌缺血再灌注损伤
作用机制
Chinese medicine
Chinese medicine compound
Myocardial ischemia-reperfusion injury
Mechanism
