miRNA调控抽动秽语综合征神经炎症中神经胶质细胞的研究进展

Research Progress on miRNA in Regulation of Glial Cells in Neuroinflammation of Tourette Syndrome

抽动秽语综合征(Tourette syndrome,TS)是一种儿童时期发生的神经精神疾病,其临床表现的特殊性和难治性共患病严重影响患儿身心健康、正常社交、学习及认知能力。TS的发病率呈上升趋势,其发病机制和治疗措施的研究不断增多,但尚未探明,仍需进一步研究。本综述重点围绕神经免疫炎症及参与神经免疫炎症的神经胶质细胞、微小RNA(microRNA,miRNA)如何调控神经胶质细胞进而影响TS发病,为今后探究TS的发生提供思路。

Tourette Syndrome(TS)is a neuropsychiatric disease that occurs in childhood,and its special clinical manifestations and refractory comorbidities seriously affect children’s physical and mental health,normal social interaction,learning and cognitive ability.The incidence of TS is on the rise.Although the relevant research is increasing,its pathogenesis and therapeutic protocols are not fully revealed and need further exploration.This study reviewed the relationship between neuroinflammation and involved neuroglial cells and the regulatory role of microRNA(miRNA)on glial cells to affect the pathogenesis of TS,providing ideas for future research on the occurrence of TS.