利拉鲁肽联合西格列汀治疗2型糖尿病的效果观察

Effect of liraglutide combined with sitagliptin on type 2 diabetes mellitus

目的探讨利拉鲁肽联合西格列汀在2型糖尿病治疗中的效果。方法抽取济宁医学院附属湖西医院2020年10月至2021年10月接诊的60例2型糖尿病患者为研究对象,按照随机数字表法分成研究组和对照组,每组30例。对照组采用利拉鲁肽治疗,研究组采用利拉鲁肽联合西格列汀治疗。治疗后比较两组患者的各项血糖指标,统计两组治疗有效率,比较两组不良反应发生率。结果研究组患者空腹血糖、糖化血红蛋白、体质指数和收缩压均低于对照组(P均<0.05);研究组患者治疗有效率(96.67%,29/30)高于对照组(80.00%,24/30),P<0.05;对照组不良反应发生率(13.33%,4/30)与研究组(10.00%,3/30)比较差异未见统计学意义(P>0.05)。结论采用利拉鲁肽联合西格列汀治疗2型糖尿病患者,可有效改善患者病情,提高治疗有效率。

Objective To study the effect of liraglutide combined with sitagliptin on type 2 diabetes mellitus.Methods A total of 60 patients with type 2 diabetes mellitus who were treated in Huxi Hospital Affiliated to Jining Medical University from October 2020 to October 2021 were selected as the study subjects.The above patients were divided into study group and control group by random number table method,with 30 patients in each group.The control group was treated with liraglutide alone,while the study group was treated with liraglutide combined with sitagliptin.After treatment,various blood glucose indicators of the two group were compared.The treatment effective rate of the two groups were counted,and the incidence of adverse reactions of the two groups were compared.Results Fasting blood glucose,glycated hemoglobin,body mass index and systolic blood pressure in the study group were lower than those in the control group(all P<0.05);the effective rate of the study group(96.67%,29/30)was higher than that of the control group(80.00%,24/30),P<0.05.There was no significant difference in the incidence of the adverse reactions between the control group(13.33%,4/30)and the study group(10.00%,3/30),P>0.05.Conclusions Liraglutide combined with sitagliptin in the treatment of type 2 diabetes mellitus can effectively improve the patient’s condition and improve the treatment effective rate.