肾移植术后消化系统恶性肿瘤临床分析

Clinical analysis of digestive system malignancy following renal transplantation

目的总结肾移植术后消化系统恶性肿瘤的临床特点及诊治经验。方法回顾性分析中山大学附属第一医院2000年1月至2022年7月随诊的56例肾移植术后消化系统肿瘤患者的临床资料。结果56例肾移植术后消化系统肿瘤患者中,男性44例,女性12例,2例为食管癌,10例为胃癌,26例为肝癌,3例为胰腺癌,2例为法特壶腹部肿瘤,13例为肠癌。结合随访期间患者的临床症状、实验室及影像学检查结果进行诊断。患者接受以外科手术为主治疗的综合治疗,存活时间为1个月~11年。结论肾移植受者术后消化系统肿瘤与病毒感染有密切关系,移植术后定期筛查肿瘤有助于早期诊断,并根据肿瘤特点尽早采取积极合适的治疗措施。

Objective To summarize the clinical characteristics,diagnosis,treatment and prognosis of digestive system malignancy following renal transplantation.Methods The clinical data on fifty-six cases of digestive system malignancy following renal transplantation between Jan 2000 and July 2022 was retrospectively analyzed.Results Among the fifty-six cases,forty-four were males and twelve were females.Two of them had esophageal cancer,ten had gastric carcinoma,twenty-six had liver cancer,three had pancreatic carcinoma,two had tumor of duodenal ampulla,and thirteen had intestinal cancer.The diagnosis was made based on the clinical symptoms,laboratory and imaging findings of the patients during follow-up.The patients received comprehensive treatment mainly with surgery.The survival time of patients ranged from one month to eleven years.Conclusion There was a close relationship between digestive system tumor and virus infection in renal transplant recipients.Regular tumor screening after transplantation was helpful for early diagnosis.According to the characteristics of the tumor,early and appropriate treatment measures should be taken.