β受体阻滞剂在脓毒症及脓毒症休克中的应用研究进展

Research progress on the application ofβreceptor blocker in sepsis and septic shock

脓毒症是一种全身炎性反应综合征,主要由感染引起的,进展及其迅速,早期未能控制感染,可迅速进展为脓毒症休克及多器官功能障碍而危及生命。脓毒症及脓毒症休克状态下可损伤心肌致心律失常,严重者可危及生命,β受体阻滞剂具有抗心率失常、抗炎及对心肌供氧平衡的作用,近来越来越多的目光转移至β受体阻滞剂运用于脓毒症及脓毒症休克的治疗。本文综述β受体阻滞剂的作用机制及其在脓毒症及脓毒症休克中的应用进展。

Sepsis is a systemic inflammatory response syndrome,mainly caused by infection,and progresses rapidly.Failure to control infection at early stage may rapidly progress to septic shock and multiple organ dysfunction,which may endanger life.In the state of sepsis and septic shock,it can damage the myocardia to result in arrhythmia,and even endanger life in severe cases.β-blockers have the effects of anti-arrhythmia,anti-inflammatory and regulating the oxygen supply balance of myocardium.Recently,much attention has been paid to the application ofβ-blockers in treatment of sepsis and septic shock.This article reviews the action mechanism ofβ-blockers and their application in sepsis and septic shock.