紫杉醇药物洗脱球囊治疗冠状动脉小血管病变的临床疗效

Clinical efficacy of paclitaxel drug-eluting balloon in the treatment of coronary small vessel disease

目的:探讨紫杉醇药物洗脱球囊治疗冠状动脉小血管病变的临床疗效。方法:选择2018年6月至2021年6月我院收治的冠状动脉小血管病变患者126例。所有患者根据介入实际情况分成紫杉醇药物洗脱球囊组62例,药物洗脱支架植入组64例。分析两组术前、术后复查冠脉造影病变最小管腔直径、管腔狭窄程度、手术指标及术后9个月心血管和出血不良事件发生率情况。结果:与药物洗脱支架植入组比较,紫杉醇药物洗脱球囊组术后的最小管腔直径长,管腔狭窄程度低,术中小血管病变释放压力小,释放时间长,术后心绞痛和再次狭窄发生率低,差异均有统计学意义(P<0.05)。结论:紫杉醇药物洗脱球囊应用于冠状动脉小血管病变患者的疗效确切,可降低心绞痛发生率,改善血管管腔狭窄程度,且术后不良事件发生较少,是冠状动脉小血管病变患者介入手术的理想方案。

Objective:To investigate the clinical efficacy of paclitaxel drug-eluting balloon in coronary small vessel disease.Methods:126 patients with coronary small vessel disease treated in our hospital from June 2018 to June 2021 were selected.All patients were divided into paclitaxel drug-eluting balloon group(62 cases)and drug-eluting stent implantation group(64 cases).The minimum lumen diameter,degree of lumen stenosis,surgical indexes and the incidence of adverse cardiovascular and bleeding events 9 months after coronary angiography were analyzed.Results:Compared with drug-eluting stent implantation group,the minimum lumen diameter of paclitaxel drug-eluting balloon group was longer,the degree of lumen stenosis was lower,the release pressure of small and medium-sized vascular lesions was smaller,the release time of small and medium-sized vascular lesions was longer,and The rates of postoperative angina pectoris and restenosis were lower,all the differences had statistically significance(P<0.05).Conclusion:Paclitaxel drug-eluting balloon is effective on patients with coronary small vessel disease.It can reduce the incidence of angina pectoris,improve the degree of vascular stenosis,and have less postoperative adverse events.It is an ideal scheme in patients with coronary small vessel disease.