同型半胱氨酸水平与幽门螺杆菌感染的相关分析

Correlation between homocysteine level and Helicobacter pylori infection

目的分析同型半胱氨酸水平与幽门螺杆菌感染的相关性。方法选取该院2020年9月至2021年9月收治的80例幽门螺杆菌感染患者(观察组)及80例无幽门螺杆菌感染患者(对照组)为研究对象,检测并比较两组研究对象同型半胱氨酸水平,采用Spearman相关分析同型半胱氨酸水平与幽门螺杆菌感染的相关性。结果观察组中同型半胱氨酸水平轻度升高、中度升高、重度升高患者构成比均明显高于对照组,同型半胱氨酸水平正常患者构成比低于对照组,差异有统计学意义(P<0.05)。观察组中幽门螺杆菌感染阳性强度为弱阳性患者的同型半胱氨酸水平正常、轻度升高构成比高于强阳性患者,中度升高、重度升高构成比低于强阳性患者,差异有统计学意义(P<0.05)。幽门螺杆菌感染与同型半胱氨酸水平呈正相关(r=0.52,P=0.011)。结论幽门螺杆菌感染患者同型半胱氨酸水平升高,且幽门螺杆菌感染阳性强度越高,同型半胱氨酸水平越高。

Objective To analyze the correlations between the level of homocysteine and Helicobacter pylori infection.Methods A total of 80 patients with Helicobacter pylori infection(observation group)and 80 patients without Helicobacter pylori infection(control group)admitted to Xi′an Daxing Hospital from September 2020 to September 2021 were selected as the study subjects.Homocysteine level was detected and compared in the two groups,Spearman correlation was used to analyze the correlation between homocysteine level and Helicobacter pylori infection.Results The proportions of mildly elevated,moderately elevated and severely elevated homocysteine in observation group were significantly higher than those in control group,and the proportion of normal homocysteine was lower than that in control group,the differences were statistically significant(P<0.05).In the observation group,the proportions of normal and mildly elevated homocysteine in weakly positive of Helicobacter pylori infection positive intensity patients were higher than those in strongly positive patients,and the proportions of moderately elevated and severely elevated homocysteine in weakly positive patients were lower than those in strongly positive patients,with statistical significance(P<0.05).Helicobacter pylori infection correlated positively with homocysteine level(r=0.52,P=0.011).Conclusion The level of homocysteine increased as Helicobacter pylori infection.The higher the positive intensity of Helicobacter pylori infection,the higher the level of homocysteine.