早产、低出生体重与尿道下裂发生风险关系的meta分析

Preterm birth,low birth weight and risk of hypospadias:a meta-analysis

目的探讨早产、低出生体重与尿道下裂发生风险的相关性。方法参照Cochrance协作网检索策略,检索自数据库建立至2022年4月中国知网、维普网、万方数据库、Pubmed、Cochrance、Embase等中英文数据库,纳入有关早产、低出生体重与尿道下裂发生风险之间关系的文献,对早产、低出生体重与尿道下裂发生风险之间的关系进行meta分析。结果检索筛选共纳入13篇文献,病例来自亚洲、欧洲、澳洲、美洲,采用Newcastle-Ottawa Scale评价,均为>6分。其中早产与尿道下裂发生风险之间关系的文献10篇,均为病例对照研究,异质性检验I2=46%,P=0.05,病例组3521例,对照组95816例,与对照组比较,早产为尿道下裂发生的危险因素(OR:2.13,95%CI:1.89~2.41),差异有统计学意义(Z=12.21,P<0.01)。低出生体重与尿道下裂发生风险之间关系的文献11篇,均为病例对照研究,异质性检验I2=47%,P=0.04,病例组2460例,对照组94260例,与对照组比较,低出生体重为尿道下裂发生的危险因素(OR:3.29,95%CI:2.57~4.22),差异有统计学意义(Z=9.40,P<0.01)。结论现有发表文献的meta分析结果显示,早产、低出生体重会增加尿道下裂的发生风险。

Objective To investigate the association between preterm birth,low birth weight and the risk of hypospadias.Methods According to the search strategy of Cochrance Collaborative Network,the China National Knowledge Internet(CNKI),VIP,Wanfang,Pubmed,Cochrance and Embase were searched from the establishment of the database to April 2022.The literature on the relationship between preterm birth,low birth weight and the risk of hypospadias was included.Meta analysis was conducted on the relationship between preterm birth,low birth weight and the risk of hypospadias.Results A total of 13 articles were included,including cases from Asia,Europe,Australia and America.Newcastle-ottawa Scale was used for evaluation,and the scores were all above 6.There were 10 articles on the relationship between preterm birth and the risk of hypospadias,all of which were case-control studies.Heterogeneity test I2=46%,P=0.05.There were 3521 cases in the case group and 95816 cases in the control group.Compared with the control group,preterm birth was a risk factor for hypospadias(OR:2.13,95%CI:1.89-2.41),and the difference was statistically significant(Z=12.21,P<0.01).There were 11 articles on the association between low birth weight and the risk of hypospadias,all of which were case-control studies.Heterogeneity test I2=47%,P=0.04.There were 2460 cases in the case group and 94260 cases in the control group.Compared with the control group,low birth weight was a risk factor for hypospadias(OR:3.29,95%CI:2.57-4.22),and the difference was statistically significant(Z=9.40,P<0.01).Conclusions Based on meta-analysis of published literature,preterm birth and low birth weight increase the risk of hypospadias.