脓毒症患者维生素C治疗的研究进展

Research progress in the treatment of sepsis with vitamin C

脓毒症是感染引起的宿主反应失调,其中氧化应激参与器官损伤的发生机制。创伤和感染导致的维生素C缺乏在危重患者中十分常见。作为一种高效的抗氧化剂,维生素C具有缓解氧化应激、减轻炎症反应、保护内皮细胞功能、减少血小板活化等作用。但目前尚无确切的临床研究证实脓毒症患者通过补充维生素C可获得明显受益。为进一步探讨脓毒症患者应用维生素C的临床价值,本文就脓毒症的病理生理学特点、维生素C的生理功能及缺乏症表现、维生素C的基础及临床试验研究等方面展开论述。

Sepsis is a host reaction disorder caused by infection,in which oxidative stress is involved in the mechanism of organ damage.Vitamin C deficiency caused by trauma and infection is very common in critically ill patients.As a highly effective antioxidant,vitamin C can alleviate oxidative stress,reduce the inflammatory response,protect endothelial cell function,and reduce platelet activation.However,no definite clinical study confirms that patients with sepsis can benefit significantly from vitamin C supplementation.In order to further explore the clinical value of vitamin C in patients with sepsis,this paper discusses the pathophysiology of sepsis,the physiological function and deficiency of vitamin C,the basic research and clinical trials of vitamin C.