新生儿持续肺动脉高压的危险因素分析

Risk factors analysis of persistent pulmonary hypertension in neonates

目的探讨新生儿持续肺动脉高压发病的危险因素。方法采用随机抽签法选取2020年6月至2022年6月在长江大学附属荆州医院诊治的96例患有持续肺动脉高压的新生儿和96例非持续肺动脉高压新生儿,分别作为研究组和对照组。收集患儿临床资料,通过多因素logistic回归分析新生儿持续肺动脉高压发病的相关危险因素。结果多因素logistic回归分析结果显示,宫内窘迫、Apgar评分、应用机械通气、剖宫产、Ⅱ型呼吸衰竭、碱剩余、氧分压、肺炎、气胸均为新生儿持续肺动脉高压的独立危险因素(P<0.05)。结论新生儿持续肺动脉高压发病的相关危险因素较多,应积极采取监测及防治措施。

Objective To explore the risk factors of neonatal persistent pulmonary hypertension.Methods A total of 96 neonates with persistent pulmonary hypertension and 96 neonates without persistent pulmonary hypertension in Jingzhou Hospital Affiliated to Yangtze University from June 2020 to June 2022 were selected as the study group and the control group respectively by random drawing method.Clinical data of the two groups were collected.Risk factors of persistent pulmonary hypertension were analyzed by multivariate logistic regression.Results Multivariate logistic regression analysis showed that intrauterine distress,Apgar score,using mechanical ventilation,cesarean section,typeⅡrespiratory failure,base excess level,partial pressure of oxygen,pneumonia and pneumothorax were independent risk factors for neonatal persistent pulmonary hypertension(P<0.05).Conclusion There are many risk factors associated with persistent pulmonary hypertension in neonates,monitoring and prevention measures should be taken actively.