^(99)m Tc-焦膦酸盐单光子显像:心脏淀粉样变分型诊断的新应用进展

^(99)m Tc-Pyrophosphate Scintigraphy:New Application in Diagnosis and Classification of Cardiac Amyloidosis

心脏淀粉样变临床常见病理类型为免疫球蛋白轻链型和甲状腺素转运蛋白相关型。两种不同类型心脏淀粉样变血清标志物、治疗方法和预后存在很大差异,早期诊断和鉴别心脏淀粉样变及分型是临床迫切需要的。^(99)m Tc-焦膦酸盐是一种骨显像剂,最近的研究显示其在心脏淀粉样变的分型诊断中起到了重要作用,现对^(99)m Tc-焦膦酸盐在心脏淀粉样变分型诊断中的认识、视觉评级和半定量评分标准的建立以及在临床的应用进展进行综述。

The immunoglobulin light chain type and transthyretin-related type are the two main clinical pathological types of cardiac amyloidosis(CA).There are great differences in serum markers,treatment methods and prognosis between the two different types of CA.Early diagnosis and differentiation of CA are urgently needed.^(99)m Tc-pyrophosphate is a bone imaging agent.Recent studies have shown that it plays an important role in the classification of CA.This paper reviews the recognition of^(99)m Tc-pyrophosphate in the classification diagnosis of CA,the visual grading evaluation and semi quantitative scoring standards,and the progress of its clinical application.