血清总胆固醇、白蛋白与胆碱酯酶联合检测在肝炎肝硬化患者中的诊断价值

Diagnostic value of combine detection of serum total cholesterol, albumin and cholinesterase in patients with hepatitis and cirrhosis

目的探讨血清总胆固醇(TC)、白蛋白(ALB)与胆碱酯酶(CHE)联合检测在肝炎肝硬化患者中的诊断价值。方法选择2021年1月至2022年5月阳江市人民医院收治的152例肝炎肝硬化患者为观察组,选择同期健康体检者同等例数为对照组,比较两组TC、ALB、CHE水平,分析观察组TC、ALB、CHE水平与Child-Pugh分级相关性,采用受试者工作特征(ROC)曲线分析TC+ALB+CHE联合检测对肝炎肝硬化的预测价值。结果观察组TC、ALB、CHE水平低于对照组,差异有统计学意义(P<0.05);Child-Pugh分级中,A级TC、ALB、CHE水平高于B级,B级高于C级,差异有统计学意义(P<0.05),Child-Pugh分级中,观察组患者肝功能随着A级、B级、C级逐渐下降,呈负相关;ROC曲线分析结果显示,TC、ALB、CHE联合检测预测曲线下面积为0.913(95%CI:0.882~0.944,P<0.05),最佳临界值为0.425,灵敏度为0.783,特异度为0.895。结论TC、ALB、CHE水平能够反映肝炎肝硬化患者肝脏受损程度,可作为肝炎肝硬化患者肝功能水平的检测指标,联合检测对肝炎肝硬化有一定预测价值。

Objective To explore the diagnostic value of combined detection of serum total cholesterol(TC),albumin(ALB)and cholinesterase(CHE)in patients with hepatitis and cirrhosis.Methods A total of 152 patients with hepatitis and cirrhosis admitted to Yangjiang People's Hospital from January 2021 to May 2022 were selected as the observation group,and the same number of healthy people who underwent physical examination during the same period were selected as the control group.The levels of TC,ALB,and CHE between the two groups were compared and analyzed.The levels of TC,ALB and CHE in the observation group were correlated with Child-Pugh classification,and the receiver operating characteristic(ROC)curve was used to analyze the predictive value of the combine detection of TC+ALB+CHE on hepatitis cirrhosis.Results The levels of TC,ALB and CHE in the observation group were lower than control group,the differences were statistically significant(P<0.05).In the Child-Pugh classification,the levels of TC,ALB and CHE in class A were higher than those in class B,and class B was higher than that in class C,and the differences were statistically significant(P<0.05).In the Child-Pugh classification,the liver function of the patients in the observation group gradually decreased with the classes A,B and C,showing a negative correlation.ROC curve analysis showed that the area under the detection prediction curve of the combination of TC,ALB and CHE was 0.913(95%CI:0.882-0.944,P<0.05),the best critical value was 0.425,the sensitivity was 0.783,and the specificity was 0.895.Conclusion The levels of TC,ALB and CHE can reflect the degree of liver damage in patients with hepatitis and cirrhosis,and can be using as indicators for the detection of liver function in patients with hepatitis and cirrhosis.The combine detection has certain predictive value for hepatitis and cirrhosis.