精神分裂症患者童年创伤经历调查及其与认知功能的相关性

Investigation of childhood trauma experience and its correlation with cognitive function in patients with schizophrenia

目的调查精神分裂症患者童年创伤经历及其与认知功能的相关性。方法选取2018年1月至2021年12月于江西省精神病院精神科就诊的81例精神分裂症患者作为调查组(有童年创伤经历者55例,无童年创伤经历者26例),另选同期陪诊的正常人群50名作为对照组。采用童年创伤问卷(CTQ)和MATRICS共认认知成套测验(MCCB)对所有对象进行童年创伤经历和认知功能调查,采用Pearson检验对童年创伤经历与认知功能的关系进行分析。结果调查组的情感忽视、躯体忽视、情感虐待和性虐待评分高于对照组,差异有统计学意义(P<0.05),两组的躯体虐待评分比较,差异无统计学意义(P>0.05)。有童年创伤经历者的空间广度评分和MCCB总分低于无童年创伤经历者,差异有统计学意义(P<0.05)。精神分裂症患者的情感忽视、躯体忽视、情感虐待、躯体虐待和性虐待CTQ得分与MCCB总分均呈负相关(P<0.05)。结论精神分裂症患者童年创伤经历与认知功能密切相关,童年创伤经历越多,认知功能下降越明显。

Objective To explore the investigation of childhood trauma experience in patients with schizophrenia and its correlation with cognitive function.Methods A total of 81 patients with schizophrenia who received treatment in the psychiatric department of Jiangxi Mental Hospital from January 2018 to December 2021 were selected as the investigation group(55 patients with childhood trauma experience,26 patients without childhood trauma experience),and 50 normal people who accompanied patients during the same period were selected as the control group.Childhood trauma questionnaire(CTQ)and MATRICS consensus cognitive battery(MCCB)were used to investigate childhood trauma experience and cognitive function of all subjects,and the Pearson test was used to analyze the relationship between childhood traumatic experience and cognitive function.Results The CTQ scores of emotional neglect,physical neglect,emotional abuse and sexual abuse in the investigation group were higher than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the score of physical abuse between the two groups(P>0.05).The spatial span score and MCCB total score of those with childhood trauma experience were lower than those without childhood trauma experience,the differences were statistically significant(P<0.05).CTQ scores of schizophrenia patients with emotional neglect,physical neglect,emotional abuse,physical abuse and sexual abuse were negatively correlated with total MCCB scores(P<0.05).Conclusion Childhood trauma experience is closely related to cognitive function in patients with schizophrenia.The more childhood trauma experience,the more obvious the decline of cognitive function.