双歧杆菌三联活菌肠溶胶囊联合阿奇霉素序贯疗法治疗对肺炎支原体肺炎腹泻患儿胃肠炎症的调节作用

Effect of Bifidobacterium triple viable enteric coated capsule combined with Azithromycin Sequential Therapy on gastrointestinal inflammation in children with diarrhea Mycoplasma pneumoniae pneumonia

目的 观察双歧杆菌三联活菌肠溶胶囊联合阿奇霉素序贯疗法治疗对肺炎支原体肺炎腹泻患儿胃肠炎症的调节作用。方法 将肺炎支原体肺炎伴腹泻的患儿106例均分为对照组和观察组。对照组采用阿奇霉素序贯疗法治疗,观察组在对照组基础上给予双歧杆菌三联活菌肠溶胶囊治疗。比较两组疗效和肠道菌群失调发生率。比较两组胃肠激素、降钙素原(PCT)、C反应蛋白(CRP)、中性粒细胞百分比(NEUT%)、嗜酸性粒细胞计数(EOS)水平。结果 观察组总有效率高于对照组(P<0.05)。治疗后,两组胃肠激素和PCT、CRP、NEUT%、EOS较治疗前下降(P<0.05),且观察组低于对照组(P<0.05)。观察组肠道菌群失调发生率低于对照组(P<0.05)。结论 双歧杆菌三联活菌肠溶胶囊联合阿奇霉素序贯疗法治疗可减轻肺炎支原体并腹泻肺炎患儿炎症反应,调节胃肠激素,降低患儿肠道菌群失调的发生。

Aim To observe the regulatory effect of bifidobacterium enteric-coated capsules combined with azithromycin sequential therapy on gastrointestinal inflammation in children with diarrheal mycoplasma pneumoniae pneumonia.Methods 106 children with mycoplasma pneumoniae pneumonia and diarrhea were divided into control group and observation group. The control group was treated with azithromycin sequential therapy, and the observation group was treated with bifidobacterium triple viable enteric coated capsules on the basis of the control group. The curative effect and the incidence of intestinal flora imbalance were compared between the two groups. The levels of gastrointestinal hormone, procalcitonin(PCT), C-reactive protein(CRP), percentage of neutrophil(NEUT%), eosinophil count(EOS) were compared between the two groups. Results The total effective rate in the observation group was higher than that in the control group(P<0.05). After treatment, gastrointestinal hormones, PCT, CRP, NEUT% and EOS in the two groups decreased compared with those before treatment(P<0.05), and the observation group was lower than the control group(P<0.05). The incidence of intestinal flora imbalance in the observation group was lower than that in the control group(P<0.05). Conclusion Bifidobacterium triple viable enteric-coated capsule combined with azithromycin sequential therapy can reduce the inflammatory reaction, regulate gastrointestinal hormones, and reduce the occurrence of intestinal flora imbalance in children with diarrhea and mycoplasma pneumonia.