摘要
多囊卵巢综合征(PCOS)是育龄妇女常见的一种复杂的内分泌及代谢异常所致的疾病,其病因及病理生理机制仍不清楚。烟酰胺单核苷酸(NMN)是烟酰胺腺嘌呤二核苷酸(NAD+)生物合成的前体,增加卵巢组织NAD+水平可改善PCOS的临床症状。NMN有非常广泛的生物药理学活性,在细胞生化功能、抗衰老、抗炎症、心脏保护、糖尿病、阿尔茨海默病和肥胖相关并发症中都起到了良好的作用。本文就NMN在PCOS患者炎症、肥胖、糖尿病及胰岛素抵抗中作用的研究进展进行综述。
Polycystic ovary syndrome(PCOS)is a common disorder caused by complex endocrine and metabolic abnormalities in women of childbearing age,the etiology and pathophysiological mechanism of PCOS are still unclear.Nicotinamide mononucleotide(NMN)is the precursor of nicotinamide adenine dinucleotide(NAD+)biosynthesis.Increasing the level of NAD+in ovarian tissue can improve the clinical symptoms of PCOS.NMN has a wide range of biopharmacological activities and plays a good role in cell biochemical function,anti-aging,anti-inflammatory,heart protection,diabetes,Alzheimer’s disease and obesity related complications.In this review,the research progress on the role of NMN in inflammation,obesity,diabetes and insulin resistance in PCOS patients was reviewed.
作者
汤瑾如
伍枫
刘慧晴
易康
王彩霞
彭翠英
李素云
TANG Jinru;WU Feng;LIU Huiqing;YI Kang;WANG Caixia;PENG Cuiying;LI Suyun(Clinical Anatomy and Reproductive Medicine Application Institute,Hengyang Medical School,University of South China,Hengyang 421001,Hunan,China;Hengyang Medical School,University of South China,Hengyang 421001,Hunan,China;Department of Biology,Hengyang Medical School,University of South China,Hengyang 421001,Hunan,China;Department of Histology and Embryology,Hengyang Medical School,University of South China,Hengyang 421001,Hunan,China)
出处
《中南医学科学杂志》
CAS
2023年第1期150-153,共4页
Medical Science Journal of Central South China
基金
湖南省自然科学基金资助项目(2021JJ30593,2021JJ30598)
湖南省大学生研究性学习与创新性实验资助项目(S202110555300)
南华大学大学生研究性学习与创新性实验资助项目(X202110555543)。
