肠道菌群与不孕症相关疾病的研究进展

Research progress on gut microbiota and infertility-related diseases

不孕症是一种生殖系统疾病,美国生殖医学协会把不孕症定义为经过12个月甚至更长时间的常规无保护性交后,无法实现临床妊娠。尽管近年来辅助生殖技术在临床广泛开展,但全球仍有超过1.86亿人患有不孕症。随着国内外不孕症患者的逐渐增加,人们越来越关注不孕症相关疾病。肠道菌群是细菌相互作用的复杂群落,肠道菌群与健康之间的关系已成为一个热门话题。近年来,研究者报道肠道菌群在不孕症的发生、发展中起着重要作用。该文对肠道菌群与不孕症相关疾病研究的主要进展进行讨论,为临床诊治及研究提供新的思路。

Infertility is a disease of the reproductive system,defined by the American Society for Reproductive Medicine as the inability to achieve a clinical pregnancy after 12 months or more of routine unprotected intercourse.Despite widespread clinical use of assisted reproductive technology in recent years,more than 186 million individuals worldwide suffer from infertility.With the gradual increase of infertile patients at home and abroad,infertility-related diseases have captivated increasing attention.Gut microbiota is a community with complex bacterial interaction.The relationship between gut microbiota and health has become a hot topic.Recent studies have reported that gut microbiota plays an important role in the occurrence and development of infertility.In this article,research progresses on gut microbiota and infertility-related diseases were reviewed,aiming to provide a novel direction for clinical diagnosis,treatment and research.