血清β_(2-)微球蛋白联合尿β_(2- )微球蛋白水平与高血压病早期肾损害的关系研究

Relationship Between Serum 2-microglobulin Combined with Urinary 2-microglobulin Level andEarly Renal Damage in Patients with Essential Hypertension

探讨血清β_(2-)微球蛋白联合尿β_(2-)微球蛋白水平与高血压病早期肾损害相关性。方法:选取我中心2018年2月-2019年2月就诊的100例高血压患者为观察组,同期来我中心接受健康体检100例为对照组。观察2组人员血清β_(2-)微球蛋白与尿β_(2-)微球蛋白检验结果水平,分析其相关性。结果:观察组BUN为(5.8±1.3)mmol/L、Cr为(74.5±14.6)μmol/L,对照组BUN为(5.7±1.5)mmol/L、Cr为(71.6±14.9)μmol/L,比较差异无统计学意义(P>0.05);观察组血清β_(2-)MG为(2.761±1.262)mg/L、尿β_(2-)MG为(137.0±131.0)μg/L,明显高于对照组的(1.635±0.591)mg/L、(51.0±33.0)μg/L,2组比较差异具有统计学意义(均P<0.05);采用Pearson对相关性进行分析,患者血清β_(2-)MG和尿β_(2-)MG值越高,高血压分期越严重,呈正相关(均P<0.05)。结论:高血压病患者血清β_(2-)MG和尿β_(2-)MG浓度明显升高,且与高血压病患者肾功能损害密切相关,具有一定的临床诊断价值。

To investigate the relationship between the level of serum 2-microglobulin combined with urine 2-microglobulin and early renal damage in patients with essential hypertension. Methods:100 patients with hypertension who came to Guicheng Sub-district Community Health Service Center in Nanhai District of Foshan from February 2018 to February 2019 were selected as the observation group, and 100 patients who came to our center dur-ing the same period were selected as the control group. The levels of serum 2-microglobulin and urine 2 -micro-globulin in the two groups were observed, and the correlation was analyzed. Results:There was no significant differ-ence in Bun (5. 8 ± 1. 3) mmol/l, CR (74. 5 ± 14. 6) mmol/l, CR (5. 7 ± 1. 5) mmol/l, CR (71. 6 ± 14. 9) mmol/l in the Observation Group (P>0. 05) . Serum 2-MG/l (2. 761 ± 1. 262) mg/l, urine 2-MG (137. 0 ± 131. 0) g/l was significantly higher than that of serum 2-MG (1. 635 ± 0. 591) mg/l and urine 2-MG was (51. 0 ±33. 0) G/l, there was significant difference between the two groups (P <0. 05). Pearson Correlation Analysis showed that the higher the serum 2-MG and urine 2-MG values, the more severe the hypertension stage and the positive correlation ( P<0 . 05 ) . Conclusion:The concentrations of 2-MG in serum and 2-MG in urine were sig-nificantly increased in patients with essential hypertension, which was closely related to renal function damage.