坏死性凋亡对卵巢生殖细胞影响的研究进展

Research Progress on the Effect of Necroptosis on Ovarian Germ Cells

坏死性凋亡作为一种程序性死亡方式,参与卵泡发育、黄体分解等生殖过程,但其在哺乳动物卵巢生殖细胞上的具体机制尚未阐明。本文综述了坏死性凋亡具体分子机制、鉴定手段及其对哺乳动物卵巢生殖细胞发育影响的研究进展,以期为坏死性凋亡在哺乳动物卵巢生殖细胞上的深入研究提供理论参考。

Necroptosis, as a programmed death method, has become a research hotspot in recent years. Studies have shown that necroptosis is involved in reproductive processes such as follicle development and corpus luteum decomposition, but its specific mechanism in mammalian ovarian germ cells has not been elucidated. In this paper, the specific molecular mechanism,identification methods and the latest research progress of necroptosis on the development of mammalian ovarian germ cells are summarized, in order to provide a theoretical reference for the in-depth study of necroptosis in mammalian ovarian germ cells.