帕瑞昔布钠联合右美托咪定对鼻内镜手术苏醒期躁动的影响

Effect of Parecoxib Sodium Combined with Dexmedetomidine on Agitation during Resuscitation of Nasal Endoscopic Surgery

目的探讨帕瑞昔布钠联合右美托咪定对鼻内镜手术苏醒期躁动的影响。方法收集2019年4月至2021年10月在我院进行鼻内镜手术患者98例,采用随机数字表法进行分组,即对照组、观察组,均49例。对照组仅静脉注射右美托咪定(0.5μg/kg),观察组静脉注射帕瑞昔布钠(40mg)联合右美托咪定(0.5μg/kg)。对比两组麻醉方案对患者苏醒期躁动的影响。结果两组患者出室时间比较,差异具有统计学意义(P<0.05),两组麻醉时间、手术时间、拔管时间、出血量比较,差异均无统计学意义(P>0.05)。两组RSAS评分在T_(1)、T_(2)点比较,差异均无统计学意义(P>0.05),两组VAS评分、VAS评分在术后2h、4h、8h比较,差异具有统计学意义(P<0.05),但在术后12h、24h比较,差异均无统计学意义(P>0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论帕瑞昔布钠联合右美托咪定应用于鼻内镜手术患者,可以有效降低RSAS评分,且术后早期镇痛效果更优。

Objective To investigate the effect of parecoxib sodium combined with dexmedetomidine on agitation during recovery period of nasal endoscopic surgery.Methods a total of 98 patients undergoing nasal endoscopic surgery in our hospital from April 2019 to October 2021 were collected and divided into control group and observation group by random number table method,including 49 patients in both groups.The control group was given dexmedetomidine(0.5μg/kg)intravenously,and the observation group was given praecoxib sodium(40mg)combined with dexmedetomidine(0.5μg/kg)intravenously.Compare the two groups of anesthesia plan on the recovery of patients agitation.Results There was statistically significant difference in out-room time between the two groups(P<0.05),while there was no statistically significant difference in anesthesia time,operation time,extubation time and blood loss between the two groups(P>0.05).There were no statistically significant differences in RSAS scores between the two groups at T_(1) and T_(2) (P>0.05),and there were statistically significant differences in VAS scores and VAS scores between the two groups at 2h,4h and 8h after surgery(P<0.05),but there were no statistically significant differences at 12h and 24h after surgery(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Parecoxib sodium combined with dexmedetomidine can effectively reduce RSAS score in patients undergoing nasal endoscopic surgery,and the early postoperative analgesia effect is better.