热炎宁合剂联合阿莫西林克拉维酸钾治疗猩红热患儿有效性和安全性研究

Study on the Efficacy and Safety of Reyanning Mixture Combined with Amoxicillin and Clavulanate Potassium in the Treatment of Children with Scarlet Fever

目的研讨猩红热患儿接受热炎宁合剂以及阿莫西林克拉维酸钾配合治疗的临床价值。方法选取2018年8月-2020年10月我院收诊的猩红热患儿70例,以随机数字表法完成分组,对照组35例接受阿莫西林克拉维酸钾单药治疗,观察组35例基于对照组用药条件施加热炎宁合剂口服,比较两组方案的临床药效、白细胞计数(WBC)、C反应蛋白(CRP)水平以及用药安全情况。结果观察组治疗后总有效率较对照组(94.3%vs71.4%)更高,比较有统计学意义(P<0.05)。观察组治疗后的WBC、CRP指标水平均低于对照组,比较有统计学意义(P<0.05)。两组发生不良反应的患儿总占比相当,无统计学意义(P>0.05)。结论热炎宁合剂与阿莫西林克拉维酸钾联合用药对猩红热患儿的治疗效果较好,能够有效抑制机体炎症反应,并保证用药安全。

Objective To study the clinical value of combined treatment with Reyanning mixture and amoxicillin clavulanate potassium in children with scarlet fever.Methods A total of 70 children with scarlet fever admitted to our hospital from August 2018 to October 2020 were selected and grouped by random number table.The control group received 35 cases of amoxicillin and clavulanate potassium monotherapy,and the observation group 35 cases Based on the medication conditions of the control group,the Reyanning mixture was administered orally,and the clinical efficacy,white blood cell count(WBC),C-reactive protein(CRP)level and medication safety of the two groups were compared.Results The total effective rate of the observation group after treatment was higher than that of the control group(94.3%vs 71.4%),which was statistically significant(P<0.05).The WBC and CRP index levels of the observation group after treatment were lower than those of the control group,which was statistically significant(P<0.05).The total proportion of children with adverse reactions in the two groups was the same,which was not statistically significant(P>0.05).Conclusion Reyanning mixture combined with amoxicillin and clavulanate potassium has a good therapeutic effect on children with scarlet fever,which can effectively inhibit the body’s inflammatory response and ensure the safety of medication.