静电纺PVDF/PAN/左氧氟沙星复合纤维膜的制备及性能

Preparation and Properties of PVDF/PAN/Levofloxacin Wound Dressing based on Electrospinning

采用静电纺丝技术以聚偏氟乙烯(PVDF)为底物,添加一定质量分数的左氧氟沙星以及聚丙烯腈(PAN)制备出一种质地柔软、轻薄、透气的复合纤维膜类伤口敷料。通过场发射扫描电镜、X射线衍射仪、红外光谱分析仪及亲水性能、抗菌性能测试和体外释药表征对制得的纤维膜进行了分析。结果表明当纺丝液中PVDF质量含量为10%时,制备出的纤维膜粗细均匀、形貌良好,经静电纺丝PVDF结构由α晶型转变为压电效应最强的β晶型,使纤维膜具备一定压电性能;当复合纺丝液中PAN质量分数为2.5%时,添加PAN制备的纤维膜较PVDF/左氧氟沙星纤维膜在相同时间内接触角大幅度下降,显著提高了复合纤维膜亲水性能;当复合纺丝液中含药量为3.5%时,制备的纤维膜释药迅速、最终释药率可达80%且抗菌性能优异适用于作伤口敷料。

With polyvinylidene fluoride(PVDF) as the substrate,levofloxacin and polyacrylonitrile(PAN) were added by electrospinning technology to prepare a soft,light and breathable composite fiber membrane wound dressing. The prepared fiber membrane was analyzed by field emission scanning electron microscope,X-ray diffraction,infrared spectrum analyzer,hydrophilicity,antibacterial property test and in vitro drug release characterization. The results show that when the mass content of PVDF in spinning solution is 10%,the prepared fiber film has uniform thickness and good appearance. After electrostatic spinning,the PVDF structure changes from α crystal form to β crystal form with the strongest piezoelectric effect,which makes the fiber film have certain piezoelectric properties. When the content of PAN in the composite spinning solution is 2.5%,the contact angle of the fiber membrane prepared by adding PAN decreases greatly in the same time as that of PVDF/levofloxacin fiber membrane,which significantly improves the hydrophilic property of the composite fiber membrane. When the drug content in the composite spinning solution is 3.5%,the prepared fiber membrane releases the drug quickly,the final drug release rate can reach 80%,and the antibacterial property is excellent,so it is suitable for wound dressing.