肺癌肿瘤血管生成DCE-MRI参数与IGF1表达的相关性

Correlation between DCE-MRI Parameters and IGF1 Expression in Tumor Angiogenesis of Lung Cancer

目的 探究肺癌肿瘤血管生成动态对比增强磁共振成像(DCE-MRI)参数与胰岛素样生长因子1(IGF1)表达的相关性。方法 选择2018年4月至2019年12月入住本院的40例经手术病理证实为肺癌的患者,根据不同分化程度分为高分化组16例,低中分化组24例。采用DCE-MRI方法检测相关参数包括容量运转参数(K^(trans))、速率常数(K_(ep))、血管外细胞外间隙容积百分比(V_(e));采用免疫组化染色方法检测肺癌组织及癌旁组织IGF1表达情况;Spearman法分析肺癌患者DCE-MRI参数与IGF1表达的相关性。结果 与癌旁组织相比,肺癌组织K^(trans)、K_(ep)、V_(e)及IGF1阳性表达率升高(P<0.05);低中分化组患者K^(trans)、K_(ep)、V_(e)及IGF1阳性表达率均显著高于高分化组(P<0.05);Spearman相关性分析结果显示,K^(trans)、K_(ep)、V_(e)与IGF1表达均呈正相关(P<0.05)。结论 DCE-MRI参数K^(trans)、K_(ep)、V_(e)与IGF1表达均呈正相关,均对肺癌临床病理特征的评估具有重要意义。

Objective To investigate the correlation between dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) parameters of tumor angiogenesis and insulin-like growth factor 1(IGF1) expression in lung cancer. Methods From April 2018 to December 2019,40 patients with lung cancer confirmed by surgery and pathology were divided into high differentiation group(16 cases),low and middle differentiation group(24 cases). DCE-MRI was used to detect the related parameters,including volume transfer constant(K^(trans)),rate constant(K_(ep)) and extravascular extracellular space fractional volume(V_(e));the expression of IGF1 in lung cancer and adjacent tissues was detected by immunohistochemistry;and Spearman method was used to analyze the correlation between DCE-MRI parameters and IGF1 expression in lung cancer patients. Results Compared with paracancer tissues,the positive expression rates of K^(trans),K_(ep),V_(e) and IGF1 in lung cancer tissues were increased(P<0.05);the K^(trans),K_(ep),V_(e) and the positive expression rate of IGF1 in the low and middle differentiation group were significantly higher than those in the high differentiation group(P<0.05);and Spearman correlation analysis showed that K^(trans),K_(ep),V_(e) were positively correlated with IGF1 expression(P<0.05). Conclusions The K^(trans),K_(ep) and V_(e) in DCE-MRI are positively correlated with the expression of IGF1,which is of great significance for the evaluation of clinicopathological characteristics of lung cancer.