神经母细胞瘤影像学危险因素的研究进展

Research Progress of Neuroblastoma Imaging Defined Risk Factors

神经母细胞瘤(NB)是儿童最常见的颅外实性恶性肿瘤,表现形式多样、恶性行为和预后各异。NB自1988年开始根据国际神经母细胞瘤分期系统(INSS)进行分期,是一种基于肿瘤切除程度的术后分期系统。2009年,国际神经母细胞瘤风险组(INRG)建立了INRG分期系统(INRGSS),该系统依赖于手术或其他治疗前确定的影像学危险因素(IDRFs),可帮助预测手术结果,并可与临床资料结合提供前期风险分层。笔者就IDRFs在NB中的作用及临床应用的研究进展进行综述。

Neuroblastoma(NB) is the most common extracranial solid malignant tumor in children,which has various manifestations,malignant behaviors and different prognosis. NB has been staging according to the International Neuroblastoma Staging System(INSS) since 1988. It is a postoperative staging system based on the degree of tumor resection. In 2009,the International Neuroblastoma Risk Group(INRG) established the INRG staging system(INRGSS),which relies on the imaging risk factors(IDRFs) determined before surgery or other treatments to help predict surgical outcomes and can combined with clinical data to provide early risk stratification. The author summarizes the research progress of the role and clinical application of IDRFs in NB.